Pomalidomide-PEG1-C2-COOH

• CAT Number: I028472
• CAS Number: 2139348-60-8
• Molecular Formula: C18H19N3O7
• Molecular Weight: 389.36
• Purity: ≥95%
• Synonyms: 3-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]propanoic acid
• InChI: InChI=1S/C18H19N3O7/c22-13-5-4-12(16(25)20-13)21-17(26)10-2-1-3-11(15(10)18(21)27)19-7-9-28-8-6-14(23)24/h1-3,12,19H,4-9H2,(H,23,24)(H,20,22,25)
• InChIKey: GXCGXOBFROXMLV-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCC(=O)O

Pomalidomide-PEG1-C2-COOH（Cat No.:I028472）is a functionalized pomalidomide-based building block designed for use in PROTAC and targeted protein degradation research. It features a pomalidomide moiety that binds cereblon (CRBN), a substrate receptor of the E3 ubiquitin ligase complex, promoting ubiquitination of the target protein. The PEG1-C2 linker offers enhanced solubility and flexibility, while the terminal carboxylic acid (COOH) group enables efficient conjugation to amine-containing ligands or scaffolds. Pomalidomide-PEG1-C2-COOH is ideal for synthesizing custom bifunctional degraders and exploring structure-activity relationships in drug discovery and chemical biology applications.