Pomalidomide-PEG1-C2-N3

For research use only. Not for therapeutic Use.

  • CAT Number: I018715
  • CAS Number: 2271036-44-1
  • Molecular Formula: C₁₇H₁₈N₆O₅
  • Molecular Weight: 386.36
  • Purity: ≥95%
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Pomalidomide-PEG1-C2-N3(Cat No.:I018715)is a conjugate of pomalidomide, a potent immunomodulatory drug, with polyethylene glycol (PEG) and a linker group (C2-N3). Pomalidomide itself is used primarily in the treatment of multiple myeloma and other hematologic cancers due to its ability to modulate the immune system, enhance T-cell response, and inhibit angiogenesis. The PEG1 linker increases solubility and stability, while the C2-N3 group likely facilitates targeted delivery of the drug. This conjugate is being explored for potential use in enhancing the efficacy and minimizing side effects of pomalidomide in cancer therapies, though more research is needed.


CAS Number 2271036-44-1
Molecular Formula C₁₇H₁₈N₆O₅
Purity ≥95%
Target E3 Ligase Ligand-Linker Conjugates
IUPAC Name 4-[2-(2-azidoethoxy)ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
InChI InChI=1S/C17H18N6O5/c18-22-20-7-9-28-8-6-19-11-3-1-2-10-14(11)17(27)23(16(10)26)12-4-5-13(24)21-15(12)25/h1-3,12,19H,4-9H2,(H,21,24,25)
InChIKey NJPMWHWTBBYBDY-UHFFFAOYSA-N
SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCN=[N+]=[N-]
Reference

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.

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