Pomalidomide-PEG1-C2-N3

• CAT Number: I018715
• CAS Number: 2271036-44-1
• Molecular Formula: C₁₇H₁₈N₆O₅
• Molecular Weight: 386.36
• Purity: ≥95%
• Target: E3 Ligase Ligand-Linker Conjugates

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].

Reference

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.