Pomalidomide-PEG4-C2-NH2

• CAT Number: I019821
• CAS Number: 2225940-52-1
• Molecular Formula: C₂₃H₃₂N₄O₈
• Molecular Weight: 492.52
• Purity: ≥95%
• Target: E3 Ligase Ligand-Linker Conjugates
• IUPAC Name: 4-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• InChI: InChI=1S/C23H32N4O8/c24-6-8-32-10-12-34-14-15-35-13-11-33-9-7-25-17-3-1-2-16-20(17)23(31)27(22(16)30)18-4-5-19(28)26-21(18)29/h1-3,18,25H,4-15,24H2,(H,26,28,29)
• InChIKey: RMLHAPHCRDKBTD-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCN

Pomalidomide-PEG4-C2-NH2（Cat No.:I019821） is a synthetic conjugate used in PROTAC technology. It combines the Pomalidomide-based cereblon ligand, known for its ability to recruit E3 ligases, with a 4-unit PEG linker and an amino group (C2-NH2). This conjugate serves as a ligand-linker module in PROTACs, which are designed to induce targeted protein degradation by recruiting the ubiquitin-proteasome system. Pomalidomide-PEG4-C2-NH2 enables the selective degradation of specific disease-causing proteins, offering a promising approach in drug discovery and development for various therapeutic applications.

Reference

[1]. Jian Jin, et al. Compositions and methods for treating ezh2-mediated cancer. WO2018081530A1.