p,p'-DDE

• CAT Number: R061815
• CAS Number: 72-55-9
• Molecular Formula: C14H8Cl4
• Molecular Weight: 318.03
• Purity: ≥95%
• Synonyms: 1-chloro-4-[2,2-dichloro-1-(4-chlorophenyl)ethenyl]benzene
• InChI: InChI=1S/C14H8Cl4/c15-11-5-1-9(2-6-11)13(14(17)18)10-3-7-12(16)8-4-10/h1-8H
• InChIKey: UCNVFOCBFJOQAL-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C(=C(Cl)Cl)C2=CC=C(C=C2)Cl)Cl

p,p’-DDE (4,4′-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[1].

Reference

[1]. Kelce WR, et al. Persistent DDT metabolite p,p’-DDE is a potent androgen receptor antagonist. Nature. 1995;375(6532):581-585.
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