PP1（Cat No.:I002248）is a selective inhibitor of Src family kinases, particularly targeting Src, Lck, and Fyn. By inhibiting these non-receptor tyrosine kinases, PP1 disrupts key signaling pathways involved in cell growth, differentiation, and survival, making it a valuable tool in cancer research. Its specificity for Src kinases has allowed researchers to study their role in various cellular processes, including cancer progression and metastasis. PP1 has also been used to investigate the signaling mechanisms of immune responses, providing insights into therapeutic targets for autoimmune diseases and cancer treatment.
| Catalog Number | I002248 |
| CAS Number | 172889-26-8 |
| Synonyms | 1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine |
| Molecular Formula | C₁₆H₁₉N₅ |
| Purity | ≥95% |
| Target | Src |
| Solubility | DMSO: 25 mg/mL |
| Storage | Store at 4°C |
| IC50 | 0.2 uM (recombinant p60c-src); 0.1 uM (PDGF b-receptor in Swiss 3T3 cell) [1] |
| IUPAC Name | 1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine |
| InChI | InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) |
| InChIKey | ZVPDNRVYHLRXLX-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)(C)C |
| Reference | </br>1:Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1). Sukackaite R, Cornacchia D, Jensen MR, Mas PJ, Blackledge M, Enervald E, Duan G, Auchynnikava T, Köhn M, Hart DJ, Buonomo SBC.Sci Rep. 2017 May 18;7(1):2119. doi: 10.1038/s41598-017-01910-1. PMID: 28522851 </br>2:The associated pyrazolopyrimidines PP1 and PP2 inhibit protein tyrosine kinase 6 activity and suppress breast cancer cell proliferation. Shim HJ, Kim HI, Lee ST.Oncol Lett. 2017 Mar;13(3):1463-1469. doi: 10.3892/ol.2017.5564. Epub 2017 Jan 2. PMID: 28454278 Free PMC Article</br>3:The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia. Rimmelé P, Esposito M, Delestré L, Guervilly JH, Ridinger-Saison M, Despras E, Moreau-Gachelin F, Rosselli F, Guillouf C.Oncotarget. 2017 Mar 14. doi: 10.18632/oncotarget.16183. [Epub ahead of print] PMID: 28415748 Free Article</br>4:Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1). Filter JJ, Williams BC, Eto M, Shalloway D, Goldberg ML.Elife. 2017 Apr 7;6. pii: e24665. doi: 10.7554/eLife.24665. [Epub ahead of print] PMID: 28387646 Free Article</br>5:PAI1: a novel PP1-interacting protein that mediates human plasma/’s anti-apoptotic effect in endothelial cells. Yao H, He G, Chen C, Yan S, Lu L, Song L, Vijayan KV, Li Q, Xiong L, Miao X, Deng X.J Cell Mol Med. 2017 Mar 11. doi: 10.1111/jcmm.13127. [Epub ahead of print] PMID: 28296156 Free Article</br>6:Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1. Alver RC, Chadha GS, Gillespie PJ, Blow JJ.Cell Rep. 2017 Mar 7;18(10):2508-2520. doi: 10.1016/j.celrep.2017.02.042. PMID: 28273463 Free PMC Article</br>7:Recruitment of PP1 to the centrosomal scaffold protein CEP192. Nasa I, Trinkle-Mulcahy L, Douglas P, Chaudhuri S, Lees-Miller SP, Lee KS, Moorhead GB.Biochem Biophys Res Commun. 2017 Mar 18;484(4):864-870. doi: 10.1016/j.bbrc.2017.02.004. Epub 2017 Feb 8. PMID: 28188792 </br>8:Liguzinediol Enhances the Inotropic Effect of Rat Hearts via Inhibition of Protein Phosphatase (PP1 and PP2A) Activities. Li S, Huang H, Zhang M, Wang W, Xue S, Gao Y, Xie M, Chen K, Liu F, Chen L.J Cardiovasc Pharmacol. 2017 Apr;69(4):236-244. doi: 10.1097/FJC.0000000000000467. PMID: 28134629 </br>9:The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton. Hoffman A, Taleski G, Sontag E.Mol Cell Neurosci. 2017 Jan 23. pii: S1044-7431(16)30141-5. doi: 10.1016/j.mcn.2017.01.005. [Epub ahead of print] Review. PMID: 28126489 </br>10:The nucleoporin MEL-28/ELYS: A PP1 scaffold during M-phase exit. Hattersley N, Desai A.Cell Cycle. 2017 Mar 19;16(6):489-490. doi: 10.1080/15384101.2017.1278929. Epub 2017 Jan 19. No abstract available. PMID: 28102742 |
