For research use only. Not for therapeutic Use.
PP5-IN-1 (Compound P053) is a competitive inhibitor of Serine/threonine protein phosphatase-5 (PP5) that binds to its catalytic domain and causes apoptosis in renal cancer[1].
| Catalog Number | I040577 |
| CAS Number | 1022417-69-1 |
| Synonyms | N-(4-benzylphenyl)-3,5-dimethyl-1,2-oxazole-4-sulfonamide |
| Molecular Formula | C18H18N2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C18H18N2O3S/c1-13-18(14(2)23-19-13)24(21,22)20-17-10-8-16(9-11-17)12-15-6-4-3-5-7-15/h3-11,20H,12H2,1-2H3 |
| InChIKey | QDUOZMMIRWIMGB-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=NO1)C)S(=O)(=O)NC2=CC=C(C=C2)CC3=CC=CC=C3 |
| Reference | [1]. Elham F Ahanin, et al. Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer. Cell Chem Biol. 2023 Oct 19;30(10):1223-1234.e12. |
