For research use only. Not for therapeutic Use.
PPACK is a synthetic peptide derivative that irreversibly and specifically inhibits thrombin-<wbr></wbr>mediated platelet activation by binding with high affinity to the active site of thrombin (K<sub>i</sub> = 0.24 nM). It has been used as an anticoagulant (100 μM) and to study thrombin-<wbr></wbr>mediated fibrin deposition, angiogenesis, and proinflammatory processes.
| Catalog Number | R064993 |
| CAS Number | 71142-71-7 |
| Synonyms | Pebac;D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone |
| Molecular Formula | C21H31ClN6O3 |
| Purity | ≥95% |
| Target | PAI-1 |
| Storage | -20°C |
| InChI | InChI=1S/C21H31ClN6O3/c22-13-18(29)16(8-4-10-26-21(24)25)27-19(30)17-9-5-11-28(17)20(31)15(23)12-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13,23H2,(H,27,30)(H4,24,25,26)/t15-,16+,17+/m1/s1 |
| InChIKey | KWPACVJPAFGBEQ-IKGGRYGDSA-N |
| SMILES | O=C([C@H](N)CC1=CC=CC=C1)N2[C@H](C(N[C@H](C(CCl)=O)CCCNC(N)=N)=O)CCC2 |
| Reference | 1.Kovach, I.M.,Kelley, P.,Eddy, C., et al. Proton bridging in the interactions of thrombin with small inhibitors. Biochemistry 48(30), 7296-7304 (2009). |
