For research use only. Not for therapeutic Use.
PPD (Cat No.:I014578) is an aromatic amine commonly used as a key ingredient in hair dyes, textiles, and certain cosmetics due to its ability to create deep, lasting colors. It works by oxidizing upon exposure to air or a developer, allowing it to bind to keratin in hair, producing a permanent dye. However, PPD is also known for causing allergic reactions in some individuals, ranging from mild skin irritation to more severe dermatitis. Due to its potential health risks, its concentration is regulated in cosmetic products to ensure safer use in personal care.
| Catalog Number | I014578 |
| CAS Number | 7755-01-3 |
| Synonyms | PPD; 20(S)-Protopanoxadiol;;(3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(2S)-2-Hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol |
| Molecular Formula | C30H52O3 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | Soluble in DMSO |
| Storage | Sealed in dry,2-8°C |
| IUPAC Name | (3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol |
| InChI | InChI=1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30-/m0/s1 |
| InChIKey | PYXFVCFISTUSOO-HKUCOEKDSA-N |
| SMILES | O[C@H]1CC[C@]2(C)[C@@]3([H])C[C@@H](O)[C@]4([H])[C@@H]([C@](CC/C=C(C)C)(O)C)CC[C@@]4(C)[C@]3(C)CC[C@@]2([H])C1(C)C |
| Reference | </br>1: Chen G, Liu J, Chen W, Xu Q, Xiao M, Hu L, Mao L, Wang X. A 20(S)-protopanoxadiol derivative overcomes multi-drug resistance by antagonizing ATP-binding cassette subfamily B member 1 transporter function. Oncotarget. 2016 Feb 23;7(8):9388-403. doi: 10.18632/oncotarget.7011. PubMed PMID: 26824187; PubMed Central PMCID: PMC4891047.</br>2: Lv D, Cao Y, Dong X, Chen X, Lou Z, Chai Y. Analysis and pharmacokinetic study of curdione in Rhizoma Curcumae by UPLC/QTOF/MS. Biomed Chromatogr. 2014 Jun;28(6):782-7. doi: 10.1002/bmc.3118. PubMed PMID: 24861744.</br>3: Liu J, Chen D, Liu P, He M, Li J, Li J, Hu L. Discovery, synthesis, and structure-activity relationships of 20(S)-protopanaxadiol (PPD) derivatives as a novel class of AMPKα2β1γ1 activators. Eur J Med Chem. 2014 May 22;79:340-9. doi: 10.1016/j.ejmech.2014.04.010. Epub 2014 Apr 4. PubMed PMID: 24747289.</br>4: Liu J, Wang X, Liu P, Deng R, Lei M, Chen W, Hu L. 20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs. Bioorg Med Chem. 2013 Jul 15;21(14):4279-87. doi: 10.1016/j.bmc.2013.04.067. Epub 2013 May 3. PubMed PMID: 23683834.</br>5: Sun L, Wang Q, Liu X, Brons NH, Wang N, Steinmetz A, Lv Y, Liao Y, Zheng H. Anti-cancer effects of 20(S)-protopanoxadiol on human acute lymphoblastic leukemia cell lines Reh and RS4;11. Med Oncol. 2011 Sep;28(3):813-21. doi: 10.1007/s12032-010-9508-1. Epub 2010 Mar 31. PubMed PMID: 20354814.</br>6: Ren HC, Sun JG, Wang GJ, A JY, Xie HT, Zha WB, Yan B, Sun FZ, Hao HP, Gu SH, Sheng LS, Shao F, Shi J, Zhou F. Sensitive determination of 20(S)-protopanaxadiol in rat plasma using HPLC-APCI-MS: application of pharmacokinetic study in rats. J Pharm Biomed Anal. 2008 Dec 15;48(5):1476-80. doi: 10.1016/j.jpba.2008.09.045. Epub 2008 Oct 8. PubMed PMID: 19022601.</br>7: Han Y, Hu XM, Jiang BH, Zhao YQ. [Optimization of biotransformation conditions of active component in Panax notoginseng stalks and leaves by Fusarium sacchari]. Ying Yong Sheng Tai Xue Bao. 2007 Dec;18(12):2801-6. Chinese. PubMed PMID: 18333458.</br></br> |
