PPI-1019

• CAT Number: I008833
• CAS Number: 290828-45-4
• Molecular Formula: C36H54N6O5
• Molecular Weight: 650.865
• Purity: ≥95%
• Synonyms: PPI-1019; PPI1019; PPI 1019; Apan;(R)-N-((R)-1-(((R)-1-(((R)-1-(((R)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-4-methyl-2-(methylamino)pentanamide
• Target: beta-amyloid protein inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (2R)-4-methyl-2-[[(2R)-2-[[(2R)-2-[[(2R)-3-methyl-2-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]butanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]pentanamide
• InChI: InChI=1S/C36H54N6O5/c1-22(2)18-27(32(37)43)39-34(45)29(20-25-14-10-8-11-15-25)40-35(46)30(21-26-16-12-9-13-17-26)41-36(47)31(24(5)6)42-33(44)28(38-7)19-23(3)4/h8-17,22-24,27-31,38H,18-21H2,1-7H3,(H2,37,43)(H,39,45)(H,40,46)(H,41,47)(H,42,44)/t27-,28-,29-,30-,31-/m1/s1
• InChIKey: TUSUWHFYKZZRIG-JQWMYKLHSA-N
• SMILES: CC(C)CC(C(=O)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC

PPI-1019 is a small-molecule compound investigated for its potential as a neuroprotective agent, particularly in the treatment of neurodegenerative disorders such as Parkinson’s disease. It acts as an antagonist of the sigma-1 receptor, which is involved in modulating various cellular processes, including neuroprotection, stress response, and neurotransmitter regulation. By targeting this receptor, PPI-1019 has shown promise in reducing neuroinflammation and protecting neurons from degeneration. Its potential to modulate neuroprotective pathways makes it a valuable compound in research aimed at developing therapies for diseases characterized by neuronal loss and dysfunction.