For research use only. Not for therapeutic Use.
PPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC50s of 1.5 and 1.0 µM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs)[1].
PPIase-Parvulin Inhibitor can inhibit the proliferation of wild-type MEFs (IC50: ~1 μM), but its effect on Pin1-/- MEFs is not significant[ 1 ].
The inhibitory potency (IC50s) of PPIase-Parvulin Inhibitor against HCT116 and HSC2 cells was 1.2 μM and 0.7 μM[1], respectively.
PPIase-Parvulin Inhibitor (1 μM; 48 h) can reduce the protein levels of cyclins D1 and B1 in HCT116 cells, but has no significant effect on cyclins E and A[1].
| Catalog Number | I011775 |
| CAS Number | 64005-90-9 |
| Synonyms | ethyl 2-[13-(2-ethoxy-2-oxoethyl)-5,7,12,14-tetraoxo-6,13-diazatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]acetate |
| Molecular Formula | C22H18N2O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H18N2O8/c1-3-31-15(25)9-23-19(27)11-5-7-13-18-14(8-6-12(17(11)18)20(23)28)22(30)24(21(13)29)10-16(26)32-4-2/h5-8H,3-4,9-10H2,1-2H3 |
| InChIKey | WNKQGFNIIHNGQM-UHFFFAOYSA-N |
| SMILES | CCOC(=O)CN1C(=O)C2=C3C(=CC=C4C3=C(C=C2)C(=O)N(C4=O)CC(=O)OCC)C1=O |
| Reference | [1]. Uchida T, et al. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol. 2003 Jan;10(1):15-24. |
