PPOH

• CAT Number: I011566
• CAS Number: 206052-01-9
• Molecular Formula: C15H18O3
• Molecular Weight: 246.30
• Purity: ≥95%
• Synonyms: 6-(2-prop-2-ynoxyphenyl)hexanoic acid
• InChI: InChI=1S/C15H18O3/c1-2-12-18-14-10-7-6-9-13(14)8-4-3-5-11-15(16)17/h1,6-7,9-10H,3-5,8,11-12H2,(H,16,17)
• InChIKey: CUNYTKVXYZYERK-UHFFFAOYSA-N
• SMILES: C#CCOC1=CC=CC=C1CCCCCC(=O)O

PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC50 values of 22 μM and 6.5 μM, respectively[1]. PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PPOH (5 μM) can inhibit CYP2C9 activity by 63 and 90%, respectively, in the absence and presence of the 30-min NADPH preincubation and 63% when the 30-min preincubation omitted NADPH[1].

Reference

[1]. Melissa A VanAlstine, et al. Effects of acetylenic epoxygenase inhibitors on recombinant cytochrome p450s. Drug Metab Dispos. 2011 Jul;39(7):1221-6.
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