PPQ-102

• CAT Number: I005534
• CAS Number: 931706-15-9
• Molecular Formula: C26H22N4O3
• Molecular Weight: 438.50
• Purity: ≥95%
• Synonyms: 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4/’,5/’:3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
• Target: CFTR
• Solubility: DMSO: ≥ 52 mg/mL
• Storage: -20°C
• IC50: 90 nM
• InChI: InChI=1S/C26H22N4O3/c1-15-13-14-19(33-15)21-24-23-20(25(31)29(3)26(32)28(23)2)22(16-9-5-4-6-10-16)30(24)18-12-8-7-11-17(18)27-21/h4-14,21,27H,1-3H3
• InChIKey: MNOOVRNGPIWJDI-UHFFFAOYSA-N
• SMILES: CC1=CC=C(O1)C2C3=C4C(C(N(C)C(N4C)=O)=O)=C(C5=CC=CC=C5)N3C6=C(C=CC=C6)N2

PPQ-102 (Cat No.: I005534) is a potent small-molecule inhibitor targeting connexin hemichannels, crucial for cell communication and ion homeostasis. It is primarily used in neurological and cardiovascular disease research, where dysregulated gap junction signaling contributes to pathologies such as neuropathy and cardiac arrhythmias. PPQ-102 exhibits high specificity and bioavailability, making it a valuable tool for studying connexin-related disorders. Researchers utilize it to explore therapeutic strategies for neurodegenerative diseases, ischemic injury, and inflammatory conditions, ensuring reliable experimental outcomes in biomedical research.

Reference

[1]. Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55. 


[2]. Stewart AK, et al. SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. Am J Physiol Cell Physiol. 2011 Aug;301(2):C289-303. 


[3]. Martin C, et al. CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur Respir J. 2013 Dec;42(6):1553-62.