PPZ-A10

• CAT Number: I040672
• CAS Number: 2941268-67-1
• Molecular Formula: C56H114N6O2
• Molecular Weight: 903.54
• Purity: ≥95%
• Synonyms: 3-(didecylamino)-N-[3-[4-[3-[3-(didecylamino)propanoylamino]propyl]piperazin-1-yl]propyl]propanamide
• InChI: InChI=1S/C56H114N6O2/c1-5-9-13-17-21-25-29-33-43-59(44-34-30-26-22-18-14-10-6-2)49-39-55(63)57-41-37-47-61-51-53-62(54-52-61)48-38-42-58-56(64)40-50-60(45-35-31-27-23-19-15-11-7-3)46-36-32-28-24-20-16-12-8-4/h5-54H2,1-4H3,(H,57,63)(H,58,64)
• InChIKey: PXNLDSAGMDIEAT-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCN(CCCCCCCCCC)CCC(=O)NCCCN1CCN(CC1)CCCNC(=O)CCN(CCCCCCCCCC)CCCCCCCCCC

PPZ-A10 is a ionizable lipid that delivered mRNA preferentially to liver and spleen immune cells.

Reference

[1]. Ni H, Hatit MZC, Zhao K, et al. Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo. Nat Commun. 2022;13(1):4766.
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