PQCA

• CAT Number: I008836
• CAS Number: 1144504-35-7 (free)
• Molecular Formula: C22H20N4O3
• Molecular Weight: 388.427
• Purity: ≥95%
• Synonyms: PQCA;1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term

PQCA(CAT: I008836) is a positive allosteric modulator of the muscarinic M1 receptor. It acts by binding to an allosteric site on the receptor and enhancing the activity of the receptor in response to the endogenous neurotransmitter acetylcholine. By modulating the M1 receptor, PQCA can influence various physiological processes mediated by this receptor subtype, including cognitive function and memory formation. As a positive allosteric modulator, PQCA enhances the receptor’s response without directly activating it, offering a potential therapeutic approach for conditions associated with M1 receptor dysfunction or impairment.

Reference

1:The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys. Lange HS, Cannon CE, Drott JT, Kuduk SD, Uslaner JM.J Pharmacol Exp Ther. 2015 Dec;355(3):442-50. doi: 10.1124/jpet.115.226712. Epub 2015 Oct 7. PMID: 26446308 Free Article2:The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer/’s disease mouse model. Puri V, Wang X, Vardigan JD, Kuduk SD, Uslaner JM.Behav Brain Res. 2015;287:96-9. doi: 10.1016/j.bbr.2015.03.029. Epub 2015 Mar 20. PMID: 25800972 3:The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. Uslaner JM, Eddins D, Puri V, Cannon CE, Sutcliffe J, Chew CS, Pearson M, Vivian JA, Chang RK, Ray WJ, Kuduk SD, Wittmann M.Psychopharmacology (Berl). 2013 Jan;225(1):21-30. doi: 10.1007/s00213-012-2788-8. Epub 2012 Jul 24. PMID: 22825578