PQR-309

• CAT Number: I000865
• CAS Number: 1225037-39-7
• Molecular Formula: C₁₇H₂₀F₃N₇O₂
• Molecular Weight: 411.39
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IUPAC Name: 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
• InChI: InChI=1S/C17H20F3N7O2/c18-17(19,20)12-9-13(21)22-10-11(12)14-23-15(26-1-5-28-6-2-26)25-16(24-14)27-3-7-29-8-4-27/h9-10H,1-8H2,(H2,21,22)
• InChIKey: ADGGYDAFIHSYFI-UHFFFAOYSA-N
• SMILES: C1COCCN1C2=NC(=NC(=N2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4

PQR-309（Cat No.:I000865）is a dual inhibitor of PI3K and mTOR signaling pathways, both of which play critical roles in cell growth, survival, and metabolism. By targeting these pathways, PQR-309 effectively disrupts cancer cell proliferation and survival, making it a promising candidate for the treatment of various cancers, including solid tumors and hematologic malignancies. Its ability to inhibit both PI3K and mTOR provides a broader therapeutic effect compared to single-target inhibitors. PQR-309 is being investigated in clinical trials for its potential in oncology and combination therapies.

Reference

[1]. Cmiljanovic Vladimir, et al. Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes and their preparation. From PCT Int. Appl. (2010), WO 2010052569 A2 20100514.