For research use only. Not for therapeutic Use.
PqsR/LasR-IN-3 (Compound 7a) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-3 also inhibits hERG with the IC50 of 109.01 µM[1].
| Catalog Number | I043553 |
| CAS Number | 2581109-51-3 |
| Synonyms | 4-(benzenesulfonyl)-N-(2-oxooxolan-3-yl)butanamide |
| Molecular Formula | C14H17NO5S |
| Purity | ≥95% |
| InChI | InChI=1S/C14H17NO5S/c16-13(15-12-8-9-20-14(12)17)7-4-10-21(18,19)11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10H2,(H,15,16) |
| InChIKey | IMWIYQHJNAXHKW-UHFFFAOYSA-N |
| SMILES | C1COC(=O)C1NC(=O)CCCS(=O)(=O)C2=CC=CC=C2 |
| Reference | [1]. Mohammad Anwar Hossain, et al. Design, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence. Eur J Med Chem. 2020 Jan 1;185:111800. |
