Pralidoxime iodide

• CAT Number: I014579
• CAS Number: 94-63-3
• Molecular Formula: C7H9IN2O
• Molecular Weight: 264.06
• Purity: ≥95%
• Synonyms: (NE)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine;iodide
• InChI: InChI=1S/C7H8N2O.HI/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H
• InChIKey: QNBVYCDYFJUNLO-UHFFFAOYSA-N
• SMILES: C[N+]1=CC=CC=C1C=NO.[I-]

Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2].
Pralidoxime iodide (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice[3].

Reference

[1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141.
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[2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111.
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[3]. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138.
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