Pramipexole dihydrochloride

• CAT Number: I008839
• CAS Number: 104632-25-9
• Molecular Formula: C10H19Cl2N3S
• Molecular Weight: 284.25
• Purity: ≥95%
• Synonyms: (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;dihydrochloride
• InChI: InChI=1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m0../s1
• InChIKey: QMNWXHSYPXQFSK-KLXURFKVSA-N
• SMILES: CCCNC1CCC2=C(C1)SC(=N2)N.Cl.Cl

Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson’s disease (PD) and restless legs syndrome (RLS)[1][2][3].
Pramipexole shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM[1].?
Pramipexole dihydrochloride (0.01-10?μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size[3].?
Pramipexole dihydrochloride attenuates levodopa-induced toxicity in mesencephalic cultures, suggests that pramipexole may be cytoprotective to dopamine neurons in tissue culture[4].
Pramipexole dihydrochloride (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals[5].?
Pramipexole dihydrochloride improves neurological recovery[5].?
Pramipexole dihydrochloride prevents ischemic cell death via mitochondrial pathways in ischemic stroke[5].

Reference

[1]. Kvernmo, T., et al. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28(8): p. 1065-78.
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[2]. Takashi Okura, et al. Blood-brain barrier transport of pramipexole, a dopamine D2 agonist. Life Sci. 2007 Apr 3;80(17):1564-71.
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[3]. Ginetta Collo, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018; 2018: 4196961.
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[4]. P M Carvey, et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna). 1997;104(2-3):209-28.
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[5]. Syed Suhail Andrabi, et al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 1; 12(8): dmm033860.
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