For research use only. Not for therapeutic Use.
Pranoprofen is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.<br>Pranoprofen inhibits ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Pranoprofen inhibits ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. Pranoprofen alone induces eIF2alpha phosphorylation, which is further increased by ER stress. Pranoprofen inhibits ER stress-induced X-box-binding protein 1 (XBP-1) splicing in the primary cultured glial cells.<br>Pranoprofen is orally administered, urinary and fecal excretions of the radioactivity within 3 days are 81.1% and 18.7% of the dose in mice, 51.5% and 39.4% in rats, 81.8% and 9.0% in guinea pigs, and 93.2% and 3.6% in rabbits, respectively.
| Catalog Number | A001104 |
| CAS Number | 52549-17-4 |
| Synonyms | Pyranoprofen |
| Molecular Formula | C15H13NO3 |
| Purity | ≥95% |
| Target | Immunology/Inflammation |
| Storage | 3 years -20C powder |
| InChIKey | TVQZAMVBTVNYLA-UHFFFAOYSA-N |
