Prazosin-d8 hydrochloride

• CAT Number: I040123
• CAS Number: 1189508-34-6
• Molecular Formula: C19H14D8ClN5O4
• Molecular Weight: 427.91
• Purity: ≥95%
• Synonyms: [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl]-(furan-2-yl)methanone;hydrochloride
• InChI: InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H/i5D2,6D2,7D2,8D2
• InChIKey: WFXFYZULCQKPIP-CADLHFACSA-N
• SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl

Prazosin-d8 hydrochloride (Cat No.: I040123) is a deuterated analog of prazosin, a selective alpha-1 adrenergic receptor antagonist. The deuteration of prazosin (replacing hydrogen atoms with deuterium) enhances its stability and can help in pharmacokinetic studies by reducing isotope effects. Prazosin is commonly used to treat hypertension and symptoms of benign prostatic hyperplasia (BPH). Prazosin-d8 hydrochloride is primarily used in research to investigate the drug’s metabolism, pharmacodynamics, and pharmacokinetics, offering insights into its therapeutic efficacy and behavior in the body.

Reference

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