Prazosin Hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: A000734
  • CAS Number: 19237-84-4
  • Molecular Formula: C19H22ClN5O4
  • Molecular Weight: 419.90
  • Purity: ≥95%
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Prazosin Hydrochloride(Cat No.:A000734)is an alpha-1 adrenergic receptor antagonist primarily used to treat hypertension and related cardiovascular conditions. By blocking alpha-1 receptors, it relaxes blood vessels, leading to a decrease in blood pressure and improved blood flow. Prazosin is also used to manage symptoms of benign prostatic hyperplasia (BPH) by relaxing smooth muscle in the bladder neck and prostate. Additionally, it is effective in treating post-traumatic stress disorder (PTSD)-related nightmares and anxiety. Its versatile therapeutic effects make it a valuable medication in both cardiovascular and psychiatric care.


Catalog Number A000734
CAS Number 19237-84-4
Synonyms

19237-84-4; Prazosin HCl; Vasoflex; Minipress; Peripress

Molecular Formula C19H22ClN5O4
Purity ≥95%
Target Neuronal Signaling
Solubility Limited solubility
Storage -20°C
IUPAC Name [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride
InChI InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
InChIKey WFXFYZULCQKPIP-UHFFFAOYSA-N
SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl
Reference

1: Shen X, Xu Q, Xu S, Li J, Zhang N, Zhang L. Preparation and transdermal
diffusion evaluation of the prazosin hydrochloride-loaded electrospun poly(vinyl
alcohol) fiber mats. J Nanosci Nanotechnol. 2014 Jul;14(7):5258-65. PubMed PMID:
24758013.

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2: Kulkarni RV, Sreedhar V, Mutalik S, Setty CM, Sa B. Interpenetrating network
hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled
release of prazosin hydrochloride through skin. Int J Biol Macromol. 2010 Nov
1;47(4):520-7. doi: 10.1016/j.ijbiomac.2010.07.009. Epub 2010 Aug 1. PubMed PMID:
20678518.
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3: Kabbaj M, Morley-Fletcher S, Le Moal M, Maccari S. Individual differences in
the effects of chronic prazosin hydrochloride treatment on hippocampal
mineralocorticoid and glucocorticoid receptors. Eur J Neurosci. 2007
Jun;25(11):3312-8. PubMed PMID: 17552999.
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4: Liu L, Wang J, Zhu S. Delivery of prazosin hydrochloride from osmotic pump
system prepared by coating the core tablet with an indentation. Drug Deliv. 2007
Apr;14(4):219-24. PubMed PMID: 17497354.
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5: Liu L, Zhu S. Preparation and characterization of inclusion complexes of
prazosin hydrochloride with beta-cyclodextrin and
hydroxypropyl-beta-cyclodextrin. J Pharm Biomed Anal. 2006 Jan 23;40(1):122-7.
Epub 2005 Aug 10. PubMed PMID: 16095859.

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6: Chernyshev VV, Stephens PW, Yatsenko AV, Ryabova OB, Makarov VA. Structural
characterization of prazosin hydrochloride and prazosin free base. J Pharm Sci.
2004 Dec;93(12):3090-5. PubMed PMID: 15514987.
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7: Legnerová Z, Huclová J, Thun R, Solich P. Sensitive fluorimetric method based
on sequential injection analysis technique used for dissolution studies and
quality control of prazosin hydrochloride in tablets. J Pharm Biomed Anal. 2004
Jan 27;34(1):115-21. PubMed PMID: 14738925.
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8: Reddy LH, Ghosh B. Enhancer aided in vitro permeation of atenolol and prazosin
hydrochloride through mice skin. Indian J Exp Biol. 2001 Jan;39(1):47-51. PubMed
PMID: 11349525.
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9: Kataoka H, Kumagai H, Hanai H. Treating familial Mediterranean fever with
prazosin hydrochloride. Ann Intern Med. 1998 Sep 1;129(5):424. PubMed PMID:
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10: Altiokka G, Tun&#231;el M. Differential pulse polarographic determination of
prazosin hydrochloride in tablets. Pharmazie. 1997 May;52(5):401-2. PubMed PMID:
9183792.

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