For research use only. Not for therapeutic Use.
PRE 084 is a high affinity selective sigma 1 agonist.
| Catalog Number | I008843 |
| CAS Number | 138847-85-5 (HCl) |
| Synonyms | PRE 084; PRE-084; PRE084. PRE-084 HCl; PRE-084 hydrochloride;Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester hydrochloride |
| Molecular Formula | C19H28ClNO3 |
| Purity | ≥95% |
| Target | sigma 1 agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| SMILES | O=C(C1(C2=CC=CC=C2)CCCCC1)OCCN3CCOCC3.[H]Cl |
| Reference | </br>1:Entrena JM, Sánchez-Fernández C, Nieto FR, González-Cano R, Yeste S, Cobos EJ, Baeyens JM. Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin. Sci Rep. 2016 Nov 25;6:37835. doi: 10.1038/srep37835. PubMed PMID: 27886264; PubMed Central PMCID: PMC5122889.</br>2:Prezzavento O, Arena E, Sánchez-Fernández C, Turnaturi R, Parenti C, Marrazzo A, Catalano R, Amata E, Pasquinucci L, Cobos EJ. (+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ(1) antagonist properties and antinociceptive effects. Eur J Med Chem. 2017 Jan 5;125:603-610. doi: 10.1016/j.ejmech.2016.09.077. PubMed PMID: 27721146. |
