PRE-084 hydrochloride

• CAT Number: I004784
• CAS Number: 75136-54-8
• Molecular Formula: C19H28ClNO3
• Molecular Weight: 353.887
• Purity: ≥95%
• Synonyms: 2-morpholinoethyl 1-phenylcyclohexanecarboxylate hydrochloride
• Target: Sigma Receptor
• Solubility: DMSO: ≥ 34 mg/mL
• Storage: Store at RT
• IC50: 44 nM
• IUPAC Name: 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate;hydrochloride
• InChI: InChI=1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H
• InChIKey: QUJWFJNHTBKCLU-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)(C2=CC=CC=C2)C(=O)OCCN3CCOCC3.Cl

PRE-084 hydrochloride (Cat.No:I004784) is a selective sigma-1 receptor agonist. It has been studied for its potential therapeutic applications in various neurological disorders, including neurodegenerative diseases, pain management, and psychiatric disorders. PRE-084 hydrochloride exhibits neuroprotective, antidepressant, and analgesic effects, making it a subject of interest for further research in these areas.

Reference

[1]. Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259(2):543-550.
[2]. Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-232.