For research use only. Not for therapeutic Use.
Prednicarbate is a Corticosteroid. The mechanism of action of prednicarbate is as a Corticosteroid Hormone Receptor Agonist. Prednicarbate is a synthetic non-halogenated double-ester derivative of the corticosteroid prednisolone with anti-inflammatory, antipruritic and vasoconstrictive properties. This agent also decreases the number of circulating lymphocytes by suppression of the production of vasodilators such as prostacyclin and nitric oxide.
| Catalog Number | R050882 |
| CAS Number | 73771-04-7 |
| Synonyms | (11β)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; Dermatop; EsCort; HOE 777; Prednisolone 17-(Ethyl Carbonate) 21-Propionate; Prednitop; Regenit; S 77-0777; |
| Molecular Formula | C27H36O8 |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Storage | Store at -20°C |
| IUPAC Name | [2-[(8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate |
| InChI | InChI=1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1 |
| InChIKey | FNPXMHRZILFCKX-KAJVQRHHSA-N |
| SMILES | CCC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)OC(=O)OCC |
| Reference | </br>1:Allergic contact dermatitis caused by prednicarbate presenting as chronic hand eczema. Otero-Rivas MM, Ruiz-González I, Pérez-Bustillo A, Rodríguez-Prieto MÁ.Contact Dermatitis. 2015 Jul;73(1):51-2. doi: 10.1111/cod.12374. Epub 2015 Apr 13. No abstract available. PMID: 25864447 </br>2:Esterase activity in excised and reconstructed human skin–biotransformation of prednicarbate and the model dye fluorescein diacetate. Bätz FM, Klipper W, Korting HC, Henkler F, Landsiedel R, Luch A, von Fritschen U, Weindl G, Schäfer-Korting M.Eur J Pharm Biopharm. 2013 Jun;84(2):374-85. doi: 10.1016/j.ejpb.2012.11.008. Epub 2012 Nov 29. PMID: 23201050 </br>3:Topical therapy with nadifloxacin cream and prednicarbate cream improves acneiform eruptions caused by the EGFR-inhibitor cetuximab – A report of 29 patients. Katzer K, Tietze J, Klein E, Heinemann V, Ruzicka T, Wollenberg A.Eur J Dermatol. 2010 Jan-Feb;20(1):82-4. doi: 10.1684/ejd.2010.0806. Epub 2009 Oct 2. PMID: 19797039 </br>4:Development of a positively charged prednicarbate nanoemulsion. Baspinar Y, Keck CM, Borchert HH.Int J Pharm. 2010 Jan 4;383(1-2):201-8. doi: 10.1016/j.ijpharm.2009.09.002. Epub 2009 Sep 10. PMID: 19747968 </br>5:Prednicarbate: a review of its pharmacological properties and therapeutic use in the treatment of dermatological disorders. Spencer CM, Wagstaff AJ.BioDrugs. 1998 Jan;9(1):61-86. PMID: 18020557 </br>6:In vitro skin absorption and drug release – a comparison of six commercial prednicarbate preparations for topical use. Lombardi Borgia S, Schlupp P, Mehnert W, Schäfer-Korting M.Eur J Pharm Biopharm. 2008 Feb;68(2):380-9. Epub 2007 May 13. PMID: 17574402 </br>7:Allergic contact dermatitis to prednicarbate presenting as lupus erythematosus. Sánchez-Pérez J, Gala SP, Jiménez YD, Fraga J, Diez AG.Contact Dermatitis. 2006 Oct;55(4):247-9. No abstract available. PMID: 16958925 </br>8:Prednicarbate (Dermatop): profile of a corticosteroid. Gupta AK, Chow M.J Cutan Med Surg. 2004 Jul-Aug;8(4):244-7. Review. PMID: 16092003 </br>9:A review of prednicarbate (Dermatop). Gupta AK, Chow M.Skin Therapy Lett. 2004 Dec-2005 Jan;9(10):5-6, 9. Review. PMID: 15657633 Free Article</br>10:Prednicarbate (dermatop): a review. Gupta AK, Chow M.J Drugs Dermatol. 2004 Sep-Oct;3(5):553-6. Review. PMID: 15552608 |
