For research use only. Not for therapeutic Use.
Prednimustine（Cat No.:I008844）is a chemotherapeutic agent that combines a corticosteroid (prednisolone) with a nitrogen mustard alkylating agent. This dual-action compound is used in the treatment of various cancers, particularly lymphomas, by suppressing the immune response and inhibiting cancer cell proliferation. The prednisolone component helps reduce inflammation and immune system activity, while the nitrogen mustard portion causes DNA cross-linking, leading to cell death. Prednimustine has been investigated for its effectiveness in treating hematologic malignancies and solid tumors. However, its use is associated with side effects like immunosuppression, and careful monitoring is required during treatment.
| Catalog Number | I008844 |
| CAS Number | 29069-24-7 |
| Molecular Formula | C35H45Cl2NO6 |
| Purity | ≥95% |
| Target | DNA Alkylator/Crosslinker |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoate |
| InChI | InChI=1S/C35H45Cl2NO6/c1-33-14-12-26(39)20-24(33)8-11-27-28-13-15-35(43,34(28,2)21-29(40)32(27)33)30(41)22-44-31(42)5-3-4-23-6-9-25(10-7-23)38(18-16-36)19-17-37/h6-7,9-10,12,14,20,27-29,32,40,43H,3-5,8,11,13,15-19,21-22H2,1-2H3/t27-,28-,29-,32+,33-,34-,35-/m0/s1 |
| InChIKey | HFVNWDWLWUCIHC-GUPDPFMOSA-N |
| SMILES | C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COC(=O)CCCC4=CC=C(C=C4)N(CCCl)CCCl)O)CCC5=CC(=O)C=C[C@]35C)O |
