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72064-79-0-Prednisolone valerate acetate Prednisolone valerate acetate

Prednisolone valerate acetate

For research use only. Not for therapeutic Use.

  • CAT Number: I035000
  • CAS Number: 72064-79-0
  • Molecular Formula: C28H38O7
  • Molecular Weight: 486.6
  • Purity: 98%
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Related Small Molecules: PQR626     5-FAM-GpYLPQTV-NH2 TFA     Poricoic acid AM    

Prednisolone valerate acetate (Cat.No:I035000) is a derivative of Prednisolone, which is a synthetic corticosteroid, metabolically interconvertible with prednisone, and an impurity of Hydrocortisone. Prednisolone 21-Acetate Valerate is used in multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer.


Catalog Number I035000
CAS Number 72064-79-0
Synonyms

Prednisolone valerate acetate; Lidomex; Acepreval;

Molecular Formula C28H38O7
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (8S,9S,10R,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl pentanoate
InChI InChI=1S/C28H38O7/c1-5-6-7-24(33)35-28(23(32)16-34-17(2)29)13-11-21-20-9-8-18-14-19(30)10-12-26(18,3)25(20)22(31)15-27(21,28)4/h10,12,14,20-22,25,31H,5-9,11,13,15-16H2,1-4H3/t20-,21-,22-,25+,26-,27-,28-/m0/s1
InChIKey DGYSDXLCLKPUBR-SLPNHVECSA-N
SMILES C[C@@]12[C@](C(COC(C)=O)=O)(OC(CCCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Reference

1: Vitali C. [Percutaneous absorption of prednisolone 17-valerate-21-acetate, a new corticosteroid for topical use]. Clin Ter. 1978 Apr 30;85(2):173-7. Italian. PubMed PMID: 657747.
2: Kobayashi F, Hattori Y, Koshi T, Nagoya T. [Effect of prednisolone 17-valerate 21-acetate on immunological responses in mice (author’s transl)]. Nihon Yakurigaku Zasshi. 1980 Sep;76(5):363-72. Japanese. PubMed PMID: 7203277.
3: Wada Y, Etoh Y, Ohira A, Ikuta J, Kato Y, Sano N. [Anti-inflammatory effects of prednisolone 17-valerate 21-acetate, a new topical corticosteroid (author’s transl)]. Nihon Yakurigaku Zasshi. 1980 Sep;76(5):333-45. Japanese. PubMed PMID: 7203275.
4: Garretts M. Controlled double-blind comparative trial with fluprednylidene acetate cream and its base. Arch Dermatol Forsch. 1975;251(3):165-8. PubMed PMID: 1091216.
5: Miyamoto A, Kitaichi Y, Uchikura K. Degradation of corticosteroids during activated sludge processing. Chem Pharm Bull (Tokyo). 2014;62(1):72-6. PubMed PMID: 24390495.
6: Nakano M, Takeuchi M, Sugeno K. Effects of dexamethasone 17-esters on adrenal weight and hydrolysis of glucocorticoid 17-esters in rat fetuses. J Pharmacobiodyn. 1981 Mar;4(3):211-6. PubMed PMID: 7252770.
7: Bircher AJ, Levy F, Langauer S, Lepoittevin JP. Contact allergy to topical corticosteroids and systemic contact dermatitis from prednisolone with tolerance of triamcinolone. Acta Derm Venereol. 1995 Nov;75(6):490-3. Review. PubMed PMID: 8651033.
8: Gianella A, Jarzyna PA, Mani V, Ramachandran S, Calcagno C, Tang J, Kann B, Dijk WJ, Thijssen VL, Griffioen AW, Storm G, Fayad ZA, Mulder WJ. Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer. ACS Nano. 2011 Jun 28;5(6):4422-33. doi: 10.1021/nn103336a. Epub 2011 May 25. PubMed PMID: 21557611; PubMed Central PMCID: PMC3296132.
9: Rampini E, Rastelli A, Cardo P. Comparative study of the vasoconstrictor activity of halopredone acetate in a modified McKenzie test. Eur J Clin Pharmacol. 1978 Dec 18;14(5):325-9. PubMed PMID: 729625.
10: Nomiyama T, Takenaka H, Kishimoto S, Katoh N. Granuloma annulare-like reaction to the bacillus Calmette-Guerin vaccination. Australas J Dermatol. 2013 Feb;54(1):e4-7. doi: 10.1111/j.1440-0960.2011.00814.x. Epub 2011 Sep 20. PubMed PMID: 23373894.
11: Kimura M, Tarumoto Y, Nakane S, Otomo S. Comparative toxicity study of hydrocortisone 17-butyrate 21-propionate (HBP) ointment and other topical corticosteroids in rats. Drugs Exp Clin Res. 1986;12(8):643-52. PubMed PMID: 3757761.
12: Singh PK, Singh G. Relative Potency of Topical Corticosteroid Preparations. Indian J Dermatol Venereol Leprol. 1985 Nov-Dec;51(6):309-312. PubMed PMID: 28164900.
13: Mizushima Y, Igarashi R, Hoshi K, Muramatsu M, Fujita A. Increase in incorporation into lymphocytes in vitro of esterified anti-inflammatory corticosteroids. Agents Actions. 1986 Oct;19(1-2):123-6. PubMed PMID: 3799370.
14: Lubach D, Kietzmann M. Investigation of the skin thinning effect of prednicarbate and other corticoids in mouse skin. Skin Pharmacol. 1988;1(3):200-6. PubMed PMID: 3272751.
15: Luzzani F, Gallico L, Glässer A. In vitro and ex vivo binding to uterine progestin receptors of the rat as a tool to assay progestational activity of glucocorticoids. Methods Find Exp Clin Pharmacol. 1982;4(4):237-42. PubMed PMID: 7121132.
16: Blaschke T, Kankate L, Kramer KD. Structure and dynamics of drug-carrier systems as studied by parelectric spectroscopy. Adv Drug Deliv Rev. 2007 Jul 10;59(6):403-10. Epub 2007 May 3. PubMed PMID: 17573146.
17: Ko DH, Heiman AS, Hudson CE, Lee HJ. New steroidal antiinflammatory antedrugs: Methyl 3,20-dioxo-9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-1,4-pregnadiene-16 alpha-carboxylate and its 21-O-acyl derivatives. Steroids. 2002 Mar;67(3-4):211-9. PubMed PMID: 11856545.
18: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2002 May;24(4):217-48. Review. PubMed PMID: 12092009.

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