Pregnenolone（Cat No.:A001199）, is a natural steroid hormone and a precursor to other steroid hormones in the human body, including progesterone, cortisol, estrogen, and testosterone. It is primarily produced in the adrenal glands, liver, and brain. Pregnenolone plays a vital role in regulating various physiological functions, such as mood, memory, and stress response. In recent years, it has gained attention as a potential nootropic supplement, believed to enhance cognitive function and memory.
| Catalog Number | A001199 |
| CAS Number | 145-13-1 |
| Synonyms | NA |
| Molecular Formula | C21H32O2 |
| Purity | ≥95% |
| Target | AChR |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | -20 ℃ |
| IUPAC Name | 1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone |
| InChI | InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 |
| InChIKey | ORNBQBCIOKFOEO-QGVNFLHTSA-N |
| SMILES | CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C |
| Reference | </br>1:Synthesis of 16α-Amino-pregnenolone Derivatives via Ionic Liquid-catalyzed aza-Michael Addition and their Evaluation as C<sub>17,20</sub>-Lyase Inhibitors. Szánti-Pintér E, Maksó L, Gömöry Á, Wouters J, Edina Herman B, Szécsi M, Mikle G, Kollár L, Skoda-Földes R.Steroids. 2017 May 11. pii: S0039-128X(17)30076-4. doi: 10.1016/j.steroids.2017.05.006. [Epub ahead of print] PMID: 28502863 </br>2:Microtubule associated protein 2 in bipolar depression: Impact of pregnenolone. Daftary S, Yon JM, Choi EK, Kim YB, Bice C, Kulikova A, Park J, Sherwood Brown E.J Affect Disord. 2017 Apr 19;218:49-52. doi: 10.1016/j.jad.2017.04.024. [Epub ahead of print] PMID: 28458115 </br>3:Quantifying endogenous androgens, estrogens, pregnenolone and progesterone metabolites in human urine by gas chromatography tandem mass spectrometry. Robles J, Marcos J, Renau N, Garrostas L, Segura J, Ventura R, Barceló B, Barceló A, Pozo OJ.Talanta. 2017 Jul 1;169:20-29. doi: 10.1016/j.talanta.2017.03.032. Epub 2017 Mar 11. PMID: 28411812 </br>4:Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation. Kodama S, Shimura T, Kuribayashi H, Abe T, Yoshinari K.Toxicol Lett. 2017 Apr 5;271:58-65. doi: 10.1016/j.toxlet.2017.02.018. Epub 2017 Feb 22. PMID: 28237809 </br>5:Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice. Busquets-Garcia A, Soria-Gómez E, Redon B, Mackenbach Y, Vallée M, Chaouloff F, Varilh M, Ferreira G, Piazza PV, Marsicano G.Mol Psychiatry. 2017 Feb 21. doi: 10.1038/mp.2017.4. [Epub ahead of print] PMID: 28220044 </br>6:Synthesis and biological evaluation of heterocyclic analogues of pregnenolone as novel anti-osteoporotic agents. Maurya SW, Dev K, Singh KB, Rai R, Siddiqui IR, Singh D, Maurya R.Bioorg Med Chem Lett. 2017 Mar 15;27(6):1390-1396. doi: 10.1016/j.bmcl.2017.02.004. Epub 2017 Feb 4. PMID: 28202325 </br>7:A sensitive and accurate LC-MS/MS assay with the derivatization of 1-Amino-4-methylpiperazine applied to serum allopregnanolone, pregnenolone and androsterone in pre- and postmenopausal women. Ke Y, Gonthier R, Labrie F.Steroids. 2017 Feb;118:25-31. doi: 10.1016/j.steroids.2016.11.007. Epub 2016 Nov 29. PMID: 27913096 </br>8:Pregnenolone sulfate regulates prolactin production in the rat pituitary. Kang EJ, Hong SH, Lee JE, Kim SC, Yang HS, Yi PI, Lee SM, An BS.J Endocrinol. 2016 Sep;230(3):339-46. doi: 10.1530/JOE-16-0088. PMID: 27507676 </br>9:Serum levels of cholesterol, pregnenolone, DHEA, and their sulfate conjugates based on sex and pubertal stage in adolescents. Kim SH, Lee SH, Lee WY, Lee J, Chung BC, Park MJ, Choi MH.Clin Chim Acta. 2016 Oct 1;461:47-52. doi: 10.1016/j.cca.2016.07.022. Epub 2016 Jul 27. PMID: 27475977 </br>10:Promnestic effects of intranasally applied pregnenolone in rats. Abdel-Hafiz L, Chao OY, Huston JP, Nikolaus S, Spieler RE, de Souza Silva MA, Mattern C.Neurobiol Learn Mem. 2016 Sep;133:185-95. doi: 10.1016/j.nlm.2016.07.012. Epub 2016 Jul 14. PMID: 27423520 |
