Prenylamine lactate

• CAT Number: I035007
• CAS Number: 69-43-2
• Molecular Formula: C27H33NO3
• Molecular Weight: 419.57
• Purity: 98%
• Synonyms: Agozol; Angormin; Prenylamine lactate
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Phenethylamine, N-(3,3-diphenylpropyl)-alpha-methyl-, lactate
• InChI: InChI=1S/C24H27N.C3H6O3/c1-20(19-21-11-5-2-6-12-21)25-18-17-24(22-13-7-3-8-14-22)23-15-9-4-10-16-23;1-2(4)3(5)6/h2-16,20,24-25H,17-19H2,1H3;2,4H,1H3,(H,5,6)
• InChIKey: QPOFIDVRLWJICD-UHFFFAOYSA-N
• SMILES: CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2)CC3=CC=CC=C3.OC(C)C(O)=O

Prenylamine lactate, a drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity.

Reference

1: Elizarov SM, Gavrilina AV, Danilenko VN. [Modulation of serine/threonine protein kinase activity in chloramphenicol-resistant mutants of Streptomyces avermitilis]. Mol Biol (Mosk). 2004 May-Jun;38(3):394-403. Russian. PubMed PMID: 15285607.
2: Pivovarov AS, Drozdova EI, Kotlyar BI. Calmodulin blockers decrease short-term plasticity of the cholinoreceptors of neurons of the edible snail. Neurosci Behav Physiol. 1991 Jul-Aug;21(4):289-95. PubMed PMID: 1721681.
3: Pivovarov AS, Drozdova EI, Kotliar BI. [Calmodulin blockaders weaken the short-term plasticity of the neuronal cholinoreceptors in the edible snail]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 May-Jun;40(3):535-42. Russian. PubMed PMID: 2169160.
4: Fan JF, Matsuda R, Ishibashi M, Takeda Y. Determination of prenylamine lactate tablets by high performance liquid chromatography. Eisei Shikenjo Hokoku. 1988;(106):91-4. PubMed PMID: 3250662.
5: Issa AS, Mahrous MS, Salam MA, Soliman N. The use of 2,3-dichloro-5,6-dicyano-p-benzoquinone for the spectrophotometric determination of some cardiovascular drugs. Talanta. 1987 Jul;34(7):670-2. PubMed PMID: 18964385.
6: Onaya T, Takazawa K, Shibata K. The inhibitory effects of calmodulin antagonists on TSH-stimulated thyroid hormone release by mouse thyroid lobes. Endocrinol Jpn. 1987 Feb;34(1):89-95. PubMed PMID: 3038506.
7: Leary WP, Asmal AC, Williams P. Prenylamine lactate in the treatment of angina pectoris. Curr Ther Res Clin Exp. 1976 Feb;19(2):180-4. PubMed PMID: 813955.
8: Arora R. Prenylamine lactate in angina pectoris. Indian Heart J. 1973 Jan;25(1):62-6. PubMed PMID: 4197199.
9: Starey F. [The formation of collaterals in the coronary vascular system of the dog. Experimental proof of the collateral formation in the dog heart following prenylamine-lactate treatment]. Arzneimittelforschung. 1972 Aug;22(8):1317-20. German. PubMed PMID: 4678393.
10: Rosenbaum M, Lennon P, Horvath T. The haemodynamic effects of prenylamine lactate. Med J Aust. 1971 May 15;1(20):1053-6. PubMed PMID: 5556989.
11: Singh I, Khanna PK, Srivastava MC, Hoon RS. Extent of possible rehabilitation of service personnel with ischaemic heart disease. Br Heart J. 1970 Sep;32(5):665-70. PubMed PMID: 5470048; PubMed Central PMCID: PMC487389.
12: Wolyvovics M, Buti A, Folle LE, Dighiero J. [Effect of prenylamine lactate in angina pectoris]. Arq Bras Cardiol. 1970 Feb;23(1):7-16. Spanish. PubMed PMID: 5451900.
13: Cardoe N. Prenylamine lactate (‘Synadrin’) in patients with angina pectoris. Br J Clin Pract. 1968 Jul;22(7):299-301. PubMed PMID: 4873075.
14: Belle MS. Prenylamine lactate in the treatment of angina pectoris. J Fla Med Assoc. 1967 Feb;54(2):116-9. PubMed PMID: 6040838.
15: STEPHENSON P, DEWAR HA, NEWELL DJ. A clinical trial of prenylamine lactate (synadrin) in the treatment of angina of effort. Scott Med J. 1963 Jul;8:279-82. PubMed PMID: 13983903.
16: PHEAR DN. Ettriol trinitrate and prenylamine lactate in angina pectoris. Br Med J. 1963 Jun 15;1(5345):1608. PubMed PMID: 13943113; PubMed Central PMCID: PMC2124303.
17: KERRIDGE DF, MAZURKIE SJ, VEREL D. A clinical trial of prenylamine lactate–a long-lasting coronary dilator drug. Can Med Assoc J. 1961 Dec 16;85:1352-3. PubMed PMID: 14455345; PubMed Central PMCID: PMC1848641.