preQ1

• CAT Number: R067036
• CAS Number: 69251-45-2
• Molecular Formula: C7H9N5O
• Molecular Weight: 179.183\
• Purity: ≥95%
• Synonyms: 7-Deaza-7-aminomethyl-guanine; 7-Aminomethyl-7-carbaguanine.
• Storage: -20°C
• IUPAC Name: 2-amino-5-(aminomethyl)-1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one
• InChI: InChI=1S/C7H9N5O/c8-1-3-2-10-5-4(3)6(13)12-7(9)11-5/h2H,1,8H2,(H4,9,10,11,12,13)
• InChIKey: MEYMBLGOKYDGLZ-UHFFFAOYSA-N
• SMILES: C1=C(C2=C(N1)NC(=NC2=O)N)CN

preQ1 (7-aminomethyl-7-deazaguanine)(CAT: R067036) is a naturally occurring intermediate in the biosynthesis of queuosine, a modified nucleoside found in the anticodon loop of tRNA molecules in bacteria and eukaryotes. preQ1 plays a crucial role in the modification of tRNA, which is essential for accurate and efficient protein translation. This compound is synthesized by microorganisms and is further converted into queuosine, which is incorporated into tRNA at the wobble position of certain codons. Research into preQ1 and its biosynthetic pathway is important for understanding the regulation of gene expression, the fidelity of protein synthesis, and the evolutionary significance of tRNA modifications. Additionally, preQ1 and its derivatives are of interest in the study of potential antimicrobial agents targeting tRNA modification pathways in pathogenic bacteria.