Presatovir

• CAT Number: I001364
• CAS Number: 1353625-73-6
• Molecular Formula: C24H30ClN7O3S
• Molecular Weight: 532.06
• Purity: ≥95%
• Target: RSV
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-[2-[(2S)-2-[5-[(3S)-3-aminopyrrolidin-1-yl]-6-methylpyrazolo[1,5-a]pyrimidin-2-yl]piperidine-1-carbonyl]-4-chlorophenyl]methanesulfonamide
• InChI: InChI=1S/C24H30ClN7O3S/c1-15-13-32-22(27-23(15)30-10-8-17(26)14-30)12-20(28-32)21-5-3-4-9-31(21)24(33)18-11-16(25)6-7-19(18)29-36(2,34)35/h6-7,11-13,17,21,29H,3-5,8-10,14,26H2,1-2H3/t17-,21-/m0/s1
• InChIKey: GOFXWTVKPWJNGD-UWJYYQICSA-N
• SMILES: CC1=CN2C(=CC(=N2)[C@@H]3CCCCN3C(=O)C4=C(C=CC(=C4)Cl)NS(=O)(=O)C)N=C1N5CC[C@@H](C5)N

Presatovir（Cat No.:I001364）is a high-purity antiviral compound targeting the respiratory syncytial virus (RSV) fusion protein. By inhibiting viral entry into host cells, it effectively disrupts the replication cycle of RSV, making it a valuable tool in virology and drug development research. Presatovir exhibits potent and selective activity against RSV, offering insights into novel therapeutic strategies for managing severe respiratory infections. Its stability and specificity make it ideal for preclinical studies, advancing the development of targeted antiviral therapies to address unmet needs in RSV treatment.

Reference

[1]. Mackman RL, et al. Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. 2015 Feb 26;58(4):1630-1643.