Prezalumab

• CAT Number: I042397
• CAS Number: 1523164-68-2
• Purity: ≥95%

Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren’s syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE)[1].
Prezalumab shows more efficacious effects than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model and collagen induced arthritis (CIA) models[1].
Prezalumab reduces B cell in cynomolgus monkeys, same as the pharmacological effect of BAFF inhibition[1].

1.19

Pharmacokinetic Properties of Prezalumab in Cynomolgus Monkeys[1].

Cynomolgus MonkeysIV 10 mg/kg
Cynomolgus MonkeysSC 10 mg/kg

Cmax (μg/mL)
264
112

Tmax (hr)

72

AUC0-inf (μg•hr/mL)
26100
23800

MRT0-inf (hr)
138
144

CL (mL/hr/kg)
0.388
0.427

Vss (mL/kg)
52.1

Reference

[1]. Zhang M, et al. Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. 2019 Nov-Dec;37(6):906-914.
 [Content Brief]