PRIMA-1

• CAT Number: I004093
• CAS Number: 5608-24-2
• Molecular Formula: C9H15NO3
• Molecular Weight: 185.22
• Purity: ≥95%
• Synonyms: 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
• Target: Apoptosis
• Solubility: DMSO: ≥ 44 mg/mL
• Storage: 2-8°C
• InChI: InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• InChIKey: RFBVBRVVOPAAFS-UHFFFAOYSA-N
• SMILES: C1CN2CCC1C(=O)C2(CO)CO

PRIMA-1 (Cat No.:I004093) is a potent activator of p53 mutants, which are commonly found in various types of human tumors. It exerts its therapeutic effects by restoring the normal function of mutant p53, a crucial tumor suppressor protein. By doing so, PRIMA-1 induces apoptosis, or programmed cell death, in tumor cells carrying p53 mutations, effectively inhibiting tumor growth. This compound holds promise as a targeted therapy for cancers with p53 mutations, providing a potential strategy to combat tumor progression and improve treatment outcomes.