For research use only. Not for therapeutic Use.
Pristimerin（Cat No.:R016219）is a naturally occurring quinone methide triterpenoid extracted from Celastraceae plants, known for its potent anticancer, anti-inflammatory, and antioxidant properties. It has shown promising activity in cancer research, primarily by inducing apoptosis and inhibiting the proteasome and NF-κB pathways, making it a potential candidate for anticancer therapies. Additionally, pristimerin exhibits antimicrobial and antimalarial effects, expanding its relevance across therapeutic fields. Pristimerin is widely studied for its effects on cellular signaling pathways, supporting advancements in cancer treatment, inflammation control, and novel drug development from natural compounds.
| CAS Number | 1258-84-0 |
| Synonyms | (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic Acid Methyl Ester; 3-Hydroxy-2-oxo-24-Nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic Acid Methyl Ester; (20α)-3-Hydroxy-2-oxo-D:A-friedo-24-noroleana-1( |
| Molecular Formula | C30H40O4 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at -20°C |
| IUPAC Name | methyl (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylate |
| InChI | InChI=1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,32H,10-15,17H2,1-7H3/t23-,26-,27-,28+,29-,30+/m1/s1 |
| InChIKey | JFACETXYABVHFD-WXPPGMDDSA-N |
| SMILES | CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)OC)C)C)C)C)O |
| Reference | 1: Yang H, Landis-Piwowar KR, Lu D, Yuan P, Li L, Reddy GP, Yuan X, Dou QP. Pristimerin induces apoptosis by targeting the proteasome in prostate cancer cells. J Cell Biochem. 2008 Jan 1;103(1):234-44. PubMed PMID: 17541980.<br /> |
