Pristinamycin IA

For research use only. Not for therapeutic Use.

  • CAT Number: I000037
  • CAS Number: 3131-03-1
  • Molecular Formula: C45H54N8O10
  • Molecular Weight: 867.00
  • Purity: ≥95%
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Pristinamycin IA(Cat No.:I000037)is a potent antibiotic used primarily for the treatment of Gram-positive bacterial infections. It belongs to the pristinamycin family of streptogramin antibiotics and acts by inhibiting protein synthesis in bacteria. Pristinamycin IA specifically targets bacterial ribosomes, binding to the 50S subunit to prevent the elongation of the polypeptide chain, thereby stopping bacterial growth. It is particularly effective against strains resistant to other antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA). This compound is often used in combination with other antibiotics for synergistic effects.


Catalog Number I000037
CAS Number 3131-03-1
Molecular Formula C45H54N8O10
Purity ≥95%
Target Bacterial
Solubility DMSO ≥ 28 mg/mL
Storage -20°C
IUPAC Name N-[3-[[4-(dimethylamino)phenyl]methyl]-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentazatricyclo[20.4.0.06,10]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide
InChI InChI=1S/C45H54N8O10/c1-6-31-42(59)52-22-11-14-32(52)43(60)51(5)34(24-27-16-18-29(19-17-27)50(3)4)44(61)53-23-20-30(54)25-33(53)39(56)49-37(28-12-8-7-9-13-28)45(62)63-26(2)36(40(57)47-31)48-41(58)38-35(55)15-10-21-46-38/h7-10,12-13,15-19,21,26,31-34,36-37,55H,6,11,14,20,22-25H2,1-5H3,(H,47,57)(H,48,58)(H,49,56)
InChIKey YGXCETJZBDTKRY-UHFFFAOYSA-N
SMILES CCC1C(=O)N2CCCC2C(=O)N(C(C(=O)N3CCC(=O)CC3C(=O)NC(C(=O)OC(C(C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=C(C=C6)N(C)C)C
Reference

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<br>[1]. Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288(2):187-92.

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