PRMT3 inhibitor 1

• CAT Number: I012289
• CAS Number: 1340875-03-7
• Molecular Formula: C15H18N4OS
• Molecular Weight: 302.39
• Purity: ≥95%
• IUPAC Name: 1-(1,2,3-benzothiadiazol-6-yl)-3-[2-(cyclohexen-1-yl)ethyl]urea
• InChI: InChI=1S/C15H18N4OS/c20-15(16-9-8-11-4-2-1-3-5-11)17-12-6-7-13-14(10-12)21-19-18-13/h4,6-7,10H,1-3,5,8-9H2,(H2,16,17,20)
• SMILES: C1CCC(=CC1)CCNC(=O)NC2=CC3=C(C=C2)N=NS3

Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3; IC50 value of 1.6 μM for inhibition of full length PRMT3 in a radioactivity-based assay). PRMT3 inhibitor 1 showed no inhibitory activity on any of the PKMTs G9a, EHMT1, SUV39H2, SETD7, and SETD8, and PRMTs PRMT1, PRMT4, PRMT5, and PRMT8.The allosteric binding site of compound 1 was localized by site-directed mutagenesis of PRMT3 and X-ray crystallography.

Reference

A. Siarheyeva et al. An allosteric inhibitor of protein arginine methyltransferase 3. Structure. 2012, 20, 1425-1435.