For research use only. Not for therapeutic Use.
PRMT5-IN-25 (compound 503) is a potent PRMT5 inhibitor with an Ki value of 0.06 nM. PRMT5-IN-25 shows antiproliferative[1].
PRMT5-IN-25 (6 days) shows antiproliferative activity with IC50s of 0.026, 0.068 µM for HCT116-MTAP null, HCT116-WT cells, respectively[1].
| Catalog Number | I040944 |
| CAS Number | 2691869-82-4 |
| Synonyms | 2-amino-3-methyl-N-[(1R)-1-pyrimidin-2-ylethyl]-N-[[5-(trifluoromethyl)pyridin-2-yl]methyl]quinoline-6-carboxamide |
| Molecular Formula | C24H21F3N6O |
| Purity | ≥95% |
| InChI | InChI=1S/C24H21F3N6O/c1-14-10-17-11-16(4-7-20(17)32-21(14)28)23(34)33(15(2)22-29-8-3-9-30-22)13-19-6-5-18(12-31-19)24(25,26)27/h3-12,15H,13H2,1-2H3,(H2,28,32)/t15-/m1/s1 |
| InChIKey | QRZCNKOBDDQUAP-OAHLLOKOSA-N |
| SMILES | CC1=CC2=C(C=CC(=C2)C(=O)N(CC3=NC=C(C=C3)C(F)(F)F)C(C)C4=NC=CC=N4)N=C1N |
| Reference | [1]. Jennifer Rebecca Allen, et al. Novel prmt5 inhibitors. WO2021163344A1. |
