For research use only. Not for therapeutic Use.
PRMT5:MEP50 PPI is a novel PRMT5:MEP50 protein-protein interaction (PRMT5:MEP50 PPI) inhibitor, shows anti-tumor activity and anti-proliferative activity of lung and prostate cancer cells[1].
PRMT5:MEP50 PPI (0-10 μM; 72 h) inhibits the growth of prostate cancer cells[1].
PRMT5:MEP50 PPI (250-1000 nM; 72 h) decreases the expression of global arginine 3 residue of histone H4 (H4R3me2s) level in prostate cancer cells[1].
PRMT5:MEP50 PPI (500 nM; 72 h) de-represseses the PRMT5: MEP50-regulated IVL gene of prostate cancer cells[1].
PRMT5:MEP50 PPI treatment inhibits multiple PRMT5-regulated pathways critical to the survival and proliferation of lung and prostate cancer cells[1].
| Catalog Number | I042707 |
| CAS Number | 3031536-71-4 |
| Synonyms | N’-[3-[(3-ethyl-5-methyl-1,2-oxazol-4-yl)methoxy]benzoyl]quinoline-2-carbohydrazide |
| Molecular Formula | C24H22N4O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H22N4O4/c1-3-20-19(15(2)32-28-20)14-31-18-9-6-8-17(13-18)23(29)26-27-24(30)22-12-11-16-7-4-5-10-21(16)25-22/h4-13H,3,14H2,1-2H3,(H,26,29)(H,27,30) |
| InChIKey | SJWRHQSLYNANNC-UHFFFAOYSA-N |
| SMILES | CCC1=NOC(=C1COC2=CC=CC(=C2)C(=O)NNC(=O)C3=NC4=CC=CC=C4C=C3)C |
| Reference | [1]. Asberry AM, et al. Discovery and Biological Characterization of PRMT5:MEP50 Protein-Protein Interaction Inhibitors. J Med Chem. 2022 Oct 7. |
