For research use only. Not for therapeutic Use.
Procarbazine HCl is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin/’s lymphoma.<br>Procarbazine plus Cu(II) induce piperidine-labile and formamidopyrimidine-DNA glycosylase-sensitive lesions at the 5/’-ACG-3/’ sequence, complementary to a hotspot of the p53 gene, and the 5/’-TG-3/’ sequence. Procarbazine causes DNA damage through non-enzymatic formation of the Cu(I)-hydroperoxo complex and methyl radicals.<br>Procarbazine causes significant decrease in testicular and epididymal weight and a drastic reduction in haploid cells and spermatogenic arrest, demonstrating variation among the test golden hamster.
| Catalog Number | A000971 |
| CAS Number | 366-70-1 |
| Synonyms | NSC-77213 HCl |
| Molecular Formula | C12H19N3O • HCl |
| Purity | ≥95% |
| Target | DNA Alkylator/Crosslinker |
| Solubility | Limited solubility |
| Storage | 3 years -20C powder |
| InChIKey | DERJYEZSLHIUKF-UHFFFAOYSA-N |
