For research use only. Not for therapeutic Use.
Procaterol is an intermediate-acting β2 adrenoreceptor agonist used for the treatment of asthma.
| Catalog Number | I011995 |
| CAS Number | 72332-33-3 |
| Synonyms | Procaterol; OPC 2009; OPC-2009; OPC2009; CI 888; CI-888; CI888.;8-hydroxy-5-((1R,2S)-1-hydroxy-2-(isopropylamino)butyl)quinolin-2(1H)-one |
| Molecular Formula | C16H22N2O3 |
| Purity | ≥95% |
| Target | β2 adrenoreceptor agonist |
| Solubility | Soluble in DMSO |
| Storage | Store at 0-8 °C |
| InChI | InChI=1S/C16H22N2O3/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20)/t12-,16+/m0/s1 |
| InChIKey | FKNXQNWAXFXVNW-BLLLJJGKSA-N |
| SMILES | O=C1NC2=C(C([C@@H](O)[C@@H](NC(C)C)CC)=CC=C2O)C=C1 |
| Reference | </br>1: Tahara K, Tomida H, Ito Y, Tachikawa S, Onodera R, Tanaka H, Tozuka Y, Takeuchi H. Pulmonary liposomal formulations encapsulated procaterol hydrochloride by a remote loading method achieve sustained release and extended pharmacological effects. Int J Pharm. 2016 May 30;505(1-2):139-46. doi: 10.1016/j.ijpharm.2016.03.031. Epub 2016 Mar 21. PubMed PMID: 27012982.</br>2: Liu JM, Huang Q, Liu ZB, Zhang LH, Zheng ZY, Lin CQ. Design of highly sensitive phosphorescence sensor for determination of procaterol hydrochloride based on inhibition of KClO3 oxidation fluorescein isothiocyanate. Luminescence. 2015 Jun;30(4):382-7. doi: 10.1002/bio.2743. Epub 2014 Jul 18. PubMed PMID: 25044504.</br>3: Kobayashi H, Masuda M, Kashiyama E, Koga N, Yasuda Y, Shibutani T, Endo K, Funaki T, Miyamoto T. Pharmacokinetic study of the oral administration of procaterol hydrochloride hydrate 50 µg in healthy adult Japanese men. Int J Clin Pharmacol Ther. 2010 Nov;48(11):744-50. PubMed PMID: 20979933.</br>4: Rao ZM, Zou P, Chen M, Xiu FR, Chen YL, Hong KJ. [Flow-injection chemiluminescence determination of procaterol hydrochloride]. Guang Pu Xue Yu Guang Pu Fen Xi. 2008 Feb;28(2):269-72. Chinese. PubMed PMID: 18479001.</br>5: Noma S, Kubota S, Matsukizono K, Tanoue A, Kumamoto T, Taira T, Mitsuyama H, Kawabata T, Suetsugu T, Iwakaw J, Koreed Y, Matsuyama W, Mizuno K, Higashimoto I, Osame M, Arimura K. [Bronchial asthma attack with lactic acidosis and hypokalemia in a case receiving high dose inhalation of procaterol hydrochloride]. Nihon Kokyuki Gakkai Zasshi. 2007 Apr;45(4):361-5. Japanese. PubMed PMID: 17491317.</br>6: Kawai M, Nakashima M, Takaori S, Nakamura Y, Akamatsu K, Nakashima M, Miyamoto T. Pharmacodynamic equivalence study of CFC-free and CFC-containing procaterol hydrochloride metered-dose inhalers. Methods Find Exp Clin Pharmacol. 2005 Oct;27(8):555-8. PubMed PMID: 16273135.</br>7: Kawai M, Sakai A, Takaori S, Hiura A, Sakata N, Nakashima M, Miyamoto T. Pharmacodynamic study of procaterol hydrochloride dry powder inhaler: evaluation of pharmacodynamic equivalence between procaterol hydrochloride dry powder inhaler and procaterol hydrochloride metered-dose inhaler in asthma patients in a randomized, double-dummy, double-blind crossover manner. Methods Find Exp Clin Pharmacol. 2005 Jul-Aug;27(6):385-9. PubMed PMID: 16179955.</br>8: Fontana GA, Lavorini F, Chiostri M, Castellani W, Boddi V, Pistolesi M. Large and small airway responses to procaterol hydrochloride administered through different extension devices in asthmatic patients. J Aerosol Med. 1999 Fall;12(3):177-85. PubMed PMID: 10623334.</br>9: Moriuchi H, Yuizono T. [Oleic acid-induced PaO2 decrease model for primary screening of drugs for hypoxemia: effects of tranexamic acid and procaterol hydrochloride on the decrease in PaO2]. Nihon Yakurigaku Zasshi. 1994 Jan;103(1):27-36. Japanese. PubMed PMID: 8314181.</br>10: Hoffstein V, Zamel N, McClean P, Chapman KR. Changes in pulmonary function and cross-sectional area of trachea and bronchi in asthmatics following inhalation of procaterol hydrochloride and ipratropium bromide. Am J Respir Crit Care Med. 1994 Jan;149(1):81-5. PubMed PMID: 8111604.</br>11: Ikeda K, Tsukino M, Nakashima A. [Clinical study on benefit and safety of frequent inhalation of aerosolized procaterol hydrochloride in aged acute asthmatics]. Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Dec;30(12):2105-11. Japanese. PubMed PMID: 1289631.</br>12: Cammarata A, Mazzarella G, Grella E, Liccardo G. [Duration of the therapeutic effect of a beta 2 stimulant (procaterol hydrochloride) in patients with asthmatiform bronchopathies]. Arch Monaldi Mal Torace. 1988 Mar-Apr;43(2):131-40. Italian. PubMed PMID: 2908377.</br>13: Morooka T, Nishima S, Ota S. Prevention of exercise-induced bronchospasm in asthmatic children. Effect of aerosol and oral procaterol hydrochloride. J Asthma. 1987;24(6):335-46. PubMed PMID: 2965139.</br>14: Spangler DL, Lutz CN, Tinkelman D. The effect of diet on the efficacy onset and duration of action of procaterol hydrochloride tablets. Ann Allergy. 1987 Jan;58(1):59-62. PubMed PMID: 2948431.</br>15: Kemp JP, Welch MJ, Meltzer EO, Orgel HA. Therapeutic efficacy and equivalence of tablet and syrup formulations of procaterol hydrochloride in childhood asthma. Ann Allergy. 1985 Oct;55(4):588-92. PubMed PMID: 2864890.</br>16: Mitsuhashi M, Kimura T, Tateno K, Morikawa A, Kuroume T. Effect of inhaled procaterol hydrochloride in children with bronchial asthma, with particular reference to duration of effect. J Asthma. 1985;22(4):203-7. PubMed PMID: 2931421.</br></br> |
