Procyanidin A2

• CAT Number: R005435
• CAS Number: 41743-41-3
• Molecular Formula: C30H24O12
• Molecular Weight: 576.51
• Purity: ≥95%
• Synonyms: Proanthocyanidin A2; Procyanidin A2
• Target: Bacterial
• IUPAC Name: (1R,5R,6R,13S,21R)-5,13-bis(3,4-dihydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.02,11.03,8.015,20]henicosa-2(11),3(8),9,15,17,19-hexaene-6,9,17,19,21-pentol
• InChI: InChI=1S/C30H24O12/c31-13-7-20(37)24-22(8-13)41-30(12-2-4-16(33)19(36)6-12)29(39)26(24)25-23(42-30)10-17(34)14-9-21(38)27(40-28(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,21,26-27,29,31-39H,9H2/t21-,26-,27-,29-,30+/m1/s1
• InChIKey: NSEWTSAADLNHNH-LSBOWGMISA-N
• SMILES: C1[C@H]([C@H](OC2=C1C(=CC3=C2[C@@H]4[C@H]([C@](O3)(OC5=CC(=CC(=C45)O)O)C6=CC(=C(C=C6)O)O)O)O)C7=CC(=C(C=C7)O)O)O

Procyanidin A2（Cat No.:R005435）is a naturally occurring flavonoid compound found in various plants, particularly in apples, grapes, and cocoa. As a type of procyanidin, it belongs to a larger class of polyphenolic compounds known for their antioxidant properties. Procyanidin A2 has been studied for its potential therapeutic applications, including cardiovascular health, due to its ability to promote vasodilation and improve blood flow. It also exhibits anti-inflammatory, anticancer, and neuroprotective effects. Procyanidin A2 is widely used in research on metabolic diseases, cancer prevention, and neurodegenerative disorders.

Reference

1.Jacques, David, et al. "Structure of the dimeric proanthocyanidin-A2 and its derivatives." Journal of the Chemical Society, Chemical Communications 15 (1973): 518-520.
2.Ibrahim, Sabrin RM, and Gamal A. Mohamed. "Litchi chinensis: medicinal uses, phytochemistry, and pharmacology." Journal of ethnopharmacology 174 (2015): 492-513.
3.Wen, Lingrong, et al. "Identification of flavonoids in litchi (Litchi chinensis Sonn.) leaf and evaluation of anticancer activities." Journal of functional foods 6 (2014): 555-563.
4.Zhang, Liudi, et al. "Inhibition of PDGF-BB-induced proliferation and migration in VSMCs by proanthocyanidin A2: Involvement of KDR and Jak-2/STAT-3/cPLA2 signaling pathways." Biomedicine & Pharmacotherapy 98 (2018): 847-855.
5.Ahangarpour, A., et al. "Preventive effects of procyanidin A2 on glucose homeostasis, pancreatic and duodenal homebox 1, and glucose transporter 2 gene expression disturbance induced by bisphenol A in male mice." J Physiol Pharmacol 67 (2016): 243-52.