For research use only. Not for therapeutic Use.
Procyanidin B3（Cat No.:I018530） is a natural product that exhibits specific inhibitory effects on histone acetyltransferases (HATs). Unlike traditional HAT inhibitors, Procyanidin B3 binds to a distinct site on the p300 protein, rather than the active site. This unique binding mechanism allows it to selectively inhibit p300-mediated acetylation of the androgen receptor, without affecting histone deacetylases (HDACs) or histone methyltransferases (HMTs). This specificity makes Procyanidin B3 a valuable tool for studying the role of p300 and androgen receptor acetylation in various biological processes and potential therapeutic applications.
| Catalog Number | I018530 |
| CAS Number | 23567-23-9 |
| Molecular Formula | C₃₀H₂₆O₁₂ |
| Purity | ≥95% |
| Target | Histone Acetyltransferase |
| Storage | 2-8°C |
| IUPAC Name | (2R,3S)-2-(3,4-dihydroxyphenyl)-8-[(2R,3S,4S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol |
| InChI | InChI=1S/C30H26O12/c31-13-7-20(37)24-23(8-13)41-29(12-2-4-16(33)19(36)6-12)27(40)26(24)25-21(38)10-17(34)14-9-22(39)28(42-30(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,22,26-29,31-40H,9H2/t22-,26-,27-,28+,29+/m0/s1 |
| InChIKey | XFZJEEAOWLFHDH-AVFWISQGSA-N |
| SMILES | C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O |
| Reference | [1]. Choi KC, et al. Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. Biochem J. 2011 Jan 1;433(1):235-44. |
