For research use only. Not for therapeutic Use.
Proflavine hemisulfate（Cat No.:I002353）is a synthetic dye used primarily as an antiseptic and antimicrobial agent. Belonging to the acridine class, it exhibits antibacterial properties, particularly against Gram-positive bacteria. It is commonly used in laboratory research to study bacterial infections and as a topical antiseptic for minor wounds. Proflavine hemisulfate is also employed in DNA binding studies due to its ability to intercalate into the double helix structure. This compound is available in various formulations, including its hemisulfate salt form, which ensures stability and solubility in water-based solutions.
| Catalog Number | I002353 |
| CAS Number | 1811-28-5 |
| Molecular Formula | C13H11N3 . 1/2 H2O4S |
| Purity | ≥95% |
| Target | Membrane Transporter/Ion Channel |
| Solubility | H2O: 22 mg/ml; DMSO <1 mg/ml |
| Storage | Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years). |
| IUPAC Name | acridine-3,6-diamine;sulfuric acid |
| InChI | InChI=1S/2C13H11N3.H2O4S/c2*14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;1-5(2,3)4/h2*1-7H,14-15H2;(H2,1,2,3,4) |
| InChIKey | YADYXCVYLIKQJX-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N.C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N.OS(=O)(=O)O |
| Reference | </br>1:Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology. Prieto SP, Powless AJ, Boice JW, Sharma SG, Muldoon TJ.PLoS One. 2015 May 11;10(5):e0125598. doi: 10.1371/journal.pone.0125598. eCollection 2015. PMID: 25962131 Free PMC Article</br>2:Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. Pridgeon JW, Klesius PH, Yildirim-Aksoy M.Vaccine. 2013 Apr 26;31(18):2222-30. doi: 10.1016/j.vaccine.2013.03.004. Epub 2013 Mar 13. PMID: 23499519 </br>3:Micellar-mediated binding interaction between proflavine hemisulfate and salicylic acid: spectroscopic insights and its analytical application. Patil DT, Mokashi VV, Kolekar GB, Patil SR.Luminescence. 2013 Nov-Dec;28(6):821-6. doi: 10.1002/bio.2437. Epub 2012 Oct 18. PMID: 23076990 </br>4:Effect of local irrigation with proflavine hemisulfate on wounds seeded with tumor cells. An experimental study. NASH SC, KETCHAM AS, SMITH RR.Ann Surg. 1962 Mar;155:465-71. No abstract available. PMID: 14478429 Free PMC Article |
