For research use only. Not for therapeutic Use.
Proflavine, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine behaves as a pore blocker for Kir3.2. Proflavine is a potential lead compound for Kir3.2-associated neurological diseases[2].
| Catalog Number | I044137 |
| CAS Number | 92-62-6 |
| Synonyms | acridine-3,6-diamine |
| Molecular Formula | C13H11N3 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2 |
| InChIKey | WDVSHHCDHLJJJR-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N |
| Reference | [1]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278. [2]. Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28. [3]. Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819. |
