For research use only. Not for therapeutic Use.
Progabide（Cat No.:R056410）also known as Gabren; Gabrene; Halogabide; SL 76-002. Progabide is an aminobutyric acid drug γ- A direct agonist of the aminobutyric acid receptor. It is used for epilepsy (especially partial seizure) and spastic state.
| Catalog Number | R056410 |
| CAS Number | 62666-20-0 |
| Synonyms | 4-[[(4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]butanamide; ?Gabren; Gabrene; Halogabide; SL 76-002; SL 76002; |
| Molecular Formula | C₁₇H₁₆ClFN₂O₂ |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| Reference | </br>1:Effects of new antiepileptic drugs and progabide on the mitogen-induced proliferative activity of mouse splenocytes. Basta-Kaim A, Budziszewska B, Leśkiewicz M, Kubera M, Jagła G, Nowak W, Czuczwar SJ, Lasoń W.Pharmacol Rep. 2008 Nov-Dec;60(6):925-32. PMID: 19211985 Free Article</br>2:Effects of some new antiepileptic drugs and progabide on glucocorticoid receptor-mediated gene transcription in LMCAT cells. Basta-Kaim A, Budziszewska B, Leśkiewicz M, Regulska M, Otczyk M, Kubera M, Jagła G, Nowak W, Luszczki JJ, Czuczwar SJ, Lasoń W.Pharmacol Rep. 2007 Sep-Oct;59(5):531-7. PMID: 18048953 Free Article</br>3:Anticonvulsant effect of progabide in rats during ontogenesis. Stanková L, Kozuchová A, Mares P.Physiol Res. 1997;46(1):47-52. PMID: 9728521 </br>4:The inhibitory effects on sexual behavior and ambulatory activity of the mixed GABAA/GABAB agonist progabide are differentially blocked by GABA receptor antagonists. Agmo A, Paredes RG, Sierra L, Garcés I.Psychopharmacology (Berl). 1997 Jan;129(1):27-34. PMID: 9122360 </br>5:In vivo and in vitro correlation of microsomal epoxide hydrolase inhibition by progabide. Kroetz DL, Loiseau P, Guyot M, Levy RH.Clin Pharmacol Ther. 1993 Nov;54(5):485-97. PMID: 8222491 </br>6:Co-administration of progabide inhibits haloperidol-induced oral dyskinesias in rats. Kaneda H, Shirakawa O, Dale J, Goodman L, Bachus SE, Tamminga CA.Eur J Pharmacol. 1992 Feb 25;212(1):43-9. PMID: 1555638 </br>7:Double-blind, placebo-controlled, cross-over trial of progabide as add-on therapy in epileptic patients. de Pasquet EG, Scaramelli A, de Cáceres MP, L/’Héritier C, Feldman S, Santana R, Aguilar J, Musch B, Morselli PL.Epilepsia. 1991 Jan-Feb;32(1):133-9. PMID: 1985823 </br>8:Simultaneous determination of progabide and its acid metabolite by reversed-phase high-performance liquid chromatography. Decourt JP, Mura P, Papet Y, Piriou A, Reiss D.J Chromatogr. 1990 Apr 27;527(1):214-9. No abstract available. PMID: 2365784 </br>9:An analysis of anticonvulsant actions of GABA agonists (progabide and baclofen) in the kindling model of epilepsy. Sato K, Morimoto K, Okamoto M, Nakamura Y, Otsuki S, Sato M.Epilepsy Res. 1990 Mar;5(2):117-24. PMID: 2158438 </br>10:Acid metabolite of progabide pharmacokinetics following single administration in the rabbit with special references to HPLC and (3H) muscimol radioreceptor assay. Brunet C, Luyckx M, Lhermitte M.Eur J Drug Metab Pharmacokinet. 1989 Oct-Dec;14(4):257-62. PMID: 2633919 |
