Proguanil-d6 hydrochloride

• CAT Number: I041401
• Molecular Formula: C11H11D6Cl2N5
• Molecular Weight: 296.23
• Purity: ≥95%
• Synonyms: (1E)-1-[amino-(4-chloroanilino)methylidene]-2-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)guanidine;hydrochloride
• InChI: InChI=1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H/i1D3,2D3
• InChIKey: SARMGXPVOFNNNG-TXHXQZCNSA-N
• SMILES: [2H]C([2H])([2H])C(C([2H])([2H])[2H])N=C(N)/N=C(\N)/NC1=CC=C(C=C1)Cl.Cl

Proguanil-d6 hydrochloride（Cat No.:I041401）is a deuterated form of proguanil, an antimalarial drug often used in combination with other medications like atovaquone to treat and prevent malaria. The deuterium substitution (d6) enhances its use in pharmacokinetic studies, allowing researchers to trace the compound’s metabolism and behavior in biological systems. Proguanil works by inhibiting the enzyme dihydrofolate reductase, which is involved in folic acid synthesis in malaria parasites. The labeled version, Proguanil-d6 hydrochloride, is valuable for studying its absorption, distribution, metabolism, and excretion (ADME), as well as its interaction with other drugs in combination therapies.