For research use only. Not for therapeutic Use.
Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a Ki value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect[1].
Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) strongly inhibits the mammalian prolyl endopeptidase with a Ki value of nM order, while the Ki value for the microbial enzyme is only of microM order (Ki=3.2 μM for Flavobacterium)[1].
| Catalog Number | I017443 |
| CAS Number | 86925-97-5 |
| Synonyms | tert-butyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate |
| Molecular Formula | C15H24N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H24N2O4/c1-15(2,3)21-14(20)17-9-5-7-12(17)13(19)16-8-4-6-11(16)10-18/h10-12H,4-9H2,1-3H3/t11-,12-/m0/s1 |
| InChIKey | CTCMMWKUMNGTPE-RYUDHWBXSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCCC1C(=O)N2CCCC2C=O |
| Reference | [1]. Yoshimoto T, et al. Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect. J Pharmacobiodyn. 1987 Dec;10(12):730-5. [2]. Yoshimoto T, et al. Comparison of inhibitory effects of prolinal-containing peptide derivatives on prolyl endopeptidases from bovine brain and Flavobacterium. J Biochem. 1985 Oct;98(4):975-9. |
