Propafenone-d5 Hydrochloride

• CAT Number: R006287
• CAS Number: 1346605-05-7
• Molecular Formula: C21H28ClNO3
• Molecular Weight: 382.94
• Purity: ≥95%
• Synonyms: 1-[2-[2-Hydroxy-3-(propylamino)propoxy-d5]phenyl]-3-phenyl-1-propanone Hydrochloride; 2’-[2-Hydroxy-3-(propylamino)propoxy-d5]-3-phenylpropiophenone Hydrochloride; Arythmol-d5; Pronon-d5; Rythmol-d5; Rytmonorm-d5
• Target: Sodium Channel
• Storage: Desiccate at +4C
• IUPAC Name: 1-[2-[1,1,2,3,3-pentadeuterio-2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
• InChI: InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H/i15D2,16D2,18D
• InChIKey: XWIHRGFIPXWGEF-FIFLIBHCSA-N
• SMILES: [2H]C([2H])(C([2H])(C([2H])([2H])OC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O)NCCC.Cl

Propafenone-d5 Hydrochloride is a deuterium-labeled version of propafenone hydrochloride, an antiarrhythmic agent used to treat and prevent various types of cardiac arrhythmias. It works by blocking sodium channels in the heart, stabilizing cardiac cell membranes, and reducing abnormal electrical activity. In pharmaceutical chemistry, it serves as an internal standard for the quantification and analysis of propafenone in biological samples through mass spectrometry, enhancing the accuracy of pharmacokinetic and bioavailability studies. Additionally, it is valuable in clinical research for studying drug metabolism and interactions.