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34183-22-7-Propafenone Hydrochloride Propafenone Hydrochloride

Propafenone Hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: A000377
  • CAS Number: 34183-22-7
  • Molecular Formula: C21H28ClNO3
  • Molecular Weight: 377.9
  • Purity: ≥95%
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Related Small Molecules: Clopidogrel     CH5424802     Fidaxomicin    
Research Areas: Ion Channel Modulation    

Propafenone Hydrochloride is a sodium channel protein inhibitor. Propafenone Hydrochloride is an inhibitor of AR.


Catalog Number A000377
CAS Number 34183-22-7
Synonyms

34183-22-7; Propafenone HCl; Rytmonorm; Pronon; Arythmol

Molecular Formula C21H28ClNO3
Purity ≥95%
Target Sodium Channel
Solubility >18.6mg/mL in DMSO
Storage -20°C
InChI 1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
InChIKey XWIHRGFIPXWGEF-UHFFFAOYSA-N
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
Reference

1: Pan L, Qian Y, Cheng M, Gu P, He Y, Xu X, Ding L. Pharmacokinetics of
propafenone hydrochloride sustained-release capsules in male beagle dogs. Acta
Pharm Sin B. 2015 Jan;5(1):74-8. doi: 10.1016/j.apsb.2014.11.003. Epub 2015 Jan
7. PubMed PMID: 26579428; PubMed Central PMCID: PMC4629124.
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2: Siva S, Thulasidhasan J, Rajendiran N. Host-guest inclusion complex of
propafenone hydrochloride with α- and β-cyclodextrins: spectral and molecular
modeling studies. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Nov;115:559-67.
doi: 10.1016/j.saa.2013.06.079. Epub 2013 Jun 29. PubMed PMID: 23872014.

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3: Ito N, Tashiro T, Morishige N, Nishimi M, Hayashida Y, Takeuchi K, Minematsu
N, Kuwahara G, Sukehiro Y. Efficacy of propafenone hydrochloride in preventing
postoperative atrial fibrillation after coronary artery bypass grafting. Heart
Surg Forum. 2010 Aug;13(4):E223-7. doi: 10.1532/HSF98.20091173. PubMed PMID:
20719723.

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4: Hu X, Xu D, Liu S, Liu Z, Liu S. Determination of propafenone hydrochloride by
flow-injection analysis coupled with resonance light scattering detection.
Luminescence. 2009 Mar-Apr;24(2):79-83. doi: 10.1002/bio.1068. PubMed PMID:
18780414.

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5: Dupuis LL, Wong B, Trope A. Stability of propafenone hydrochloride in i.v.
solutions. Am J Health Syst Pharm. 1997 Jun 1;54(11):1293-5. PubMed PMID:
9179350.
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6: Candinas R, Gloor HO, Lindner W, Ha HR, Buchinger W, Amann FW, Follath F. Are
there stereoselective electrophysiologic effects of intravenously administered
(S)- or (R)-propafenone hydrochloride in patients with supraventricular
tachycardia? Eur J Clin Pharmacol. 1996;50(3):185-90. PubMed PMID: 8737757.

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7: Telichowski A, Banasiak W, Ponikowski P, Wiech K, Zebrowski J, Pieróg M, Ka&#322;ka
D, Lacheta W, Fuglewicz A, Molenda W, et al. [Effect of propafenone hydrochloride
on atrial signal-averaged ECG in patients with paroxysmal atrial fibrillation].
Pol Arch Med Wewn. 1995 Aug;94(2):132-43. Polish. PubMed PMID: 8596748.

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8: Drici MD, Sbirrazzuoli V, Garraffo R, Wajman A, Morand P, Lapalus P. Effect of
propafenone hydrochloride on lymphocyte membrane beta 2 adrenoceptors in
ventricular arrhythmias. Am J Cardiol. 1989 Sep 15;64(10):671-4. PubMed PMID:
2476926.
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9: Villafane J, Gelband H, Xu H, McCormack J, Stolfi A, Pickoff AS. The
electrophysiologic effects of propafenone hydrochloride in the neonatal canine.
Pediatr Res. 1987 Jul;22(1):50-4. PubMed PMID: 3627871.
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10: Doherty JU, Waxman HL, Kienzle MG, Cassidy DM, Marchlinski FE, Buxton AE,
Josephson ME. Limited role of intravenous propafenone hydrochloride in the
treatment of sustained ventricular tachycardia: electrophysiologic effects and
results of programmed ventricular stimulation. J Am Coll Cardiol. 1984
Aug;4(2):378-81. PubMed PMID: 6736479.

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