For research use only. Not for therapeutic Use.
Propanol-PEG4-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044549 |
| CAS Number | 156868-17-6 |
| Synonyms | 3-[2-[2-[2-(3-hydroxypropoxy)ethoxy]ethoxy]ethoxy]propan-1-ol |
| Molecular Formula | C12H26O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H26O6/c13-3-1-5-15-7-9-17-11-12-18-10-8-16-6-2-4-14/h13-14H,1-12H2 |
| InChIKey | XUTTYRHTHFNTBZ-UHFFFAOYSA-N |
| SMILES | C(CO)COCCOCCOCCOCCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
