Propaphos

• CAT Number: I035060
• CAS Number: 7292-16-2
• Molecular Formula: C13H21O4PS
• Molecular Weight: 304.34
• Purity: 98%
• Synonyms: Propaphos; Kayaphos; Kayphosnac
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Phosphoric acid, 4-(methylthio)phenyl dipropyl ester (9CI)
• InChI: InChI=1S/C13H21O4PS/c1-4-10-15-18(14,16-11-5-2)17-12-6-8-13(19-3)9-7-12/h6-9H,4-5,10-11H2,1-3H3
• InChIKey: PWYIUEFFPNVCMW-UHFFFAOYSA-N
• SMILES: O=P(OCCC)(OCCC)OC1=CC=C(SC)C=C1

Propaphos (Cat.No:I035060) is an organophosphorus compound primarily used as an insecticide and acaricide. It acts by inhibiting acetylcholinesterase, an enzyme necessary for proper nervous system function in pests. Propaphos is commonly employed in agriculture and veterinary applications for the control of pests such as mites, ticks, and fleas.

Reference

1: Yamada S, Okudaira H, Hayashi E. An alteration in sensitivity to cholinergic agents on guinea-pig ilea and atria after repeated administration of an organophosphate and an antagonism by a carbamate. Arch Int Pharmacodyn Ther. 1979 Sep;241(1):32-44. PubMed PMID: 526070.
2: Nagayama M, Akahori F, Chiwata H, Shirai M, Motoya M, Masaoka T, Sakaguchi K. Effects of selected organophosphate insecticides on serum cholinesterase isoenzyme patterns in the rat. Vet Hum Toxicol. 1996 Jun;38(3):196-9. PubMed PMID: 8727219.
3: Sakaguchi K, Nagayama M, Masaoka T, Nishimura A, Kageyama K, Shirai M, Akahori F. Effects of fenthion, isoxathion, dichlorvos and propaphos on the serum cholinesterase isoenzyme patterns of dogs. Vet Hum Toxicol. 1997 Feb;39(1):1-5. PubMed PMID: 9004458.
4: Yamada S, Katsuoka M, Okudaira H, Hayashi E. A pharmacological comparison of organophosphorus and carbamate anti-cholinesterase agents on guinea pig ileum. Toxicol Appl Pharmacol. 1982 Jun 15;64(1):79-87. PubMed PMID: 7112587.
5: Okudaira H, Matsui S, Hayashi S, Yamada S, Isogai M, Shinozuka K, Hayashi E. [Toxicity and general pharmacological effects of 4-methylthiophenyl dipropyl phosphate]. Yakugaku Zasshi. 1984 Apr;104(4):374-83. Japanese. PubMed PMID: 6491875.